{"id":9407,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/diseno-sintesis-y-evaluacion-biologica-preliminar-de-nuevos-derivados-de-pirimido54-bindol-como-inhibidores-de-la-transcriptasa-inversa-del-vih-1\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"diseno-sintesis-y-evaluacion-biologica-preliminar-de-nuevos-derivados-de-pirimido54-bindol-como-inhibidores-de-la-transcriptasa-inversa-del-vih-1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/diseno-sintesis-y-evaluacion-biologica-preliminar-de-nuevos-derivados-de-pirimido54-bindol-como-inhibidores-de-la-transcriptasa-inversa-del-vih-1\/","title":{"rendered":"Dise\u00f1o, sintesis y evaluacion biologica preliminar de nuevos derivados de pirimido(5,4-b)indol como inhibidores de la transcriptasa inversa del vih-1."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Isidro Merino Fernandez <\/strong><\/h2>\n<p>Debido a la gran cantidad de inhibidores de la transcriptasa inversa del vih-1 con estructura indolica y pirimidinica asi como con estructuras triciclicas polinitrogenadas encontrados en la bibliografia, se plantea la sintesis y evaluacion biologica de derivados de pirimido (5,4-b) indol como inhibidores de dicha enzima. El anillo de pirimido (5,4-b) indol se sintetizo a partir de derivados de 3-aminoindol-2-carboxilato de etilo con y sin sustituyentes en las posiciones 5 y 6.  estas moleculas reaccionan con una gran variedad de nitrilos en condiciones acidas rindiendo los correspondientes pirimido(5,4-b) indoles 2,4 y 2,4,7,8 sustituidos. Se prepararon otras series de derivados de pirimido (5,4-b) indol a partir de las moleculas anteriores como productos de partida.  todos los compuestos se evaluaron como inhibidores de la transcriptasa inversa del vih-1 del tipo silvestre. Los compuestos activos se evaluaron como inhibidores de la enzima mutante y181c. Tambien se evaluo la citotoxicidad y la inhibicion de la formacion de sincitios de los compuestos activos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dise\u00f1o, sintesis y evaluacion biologica preliminar de nuevos derivados de pirimido(5,4-b)indol como inhibidores de la transcriptasa inversa del vih-1.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dise\u00f1o, sintesis y evaluacion biologica preliminar de nuevos derivados de pirimido(5,4-b)indol como inhibidores de la transcriptasa inversa del vih-1. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Isidro Merino Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Monge Vega<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Sanchez Gonzalez <\/li>\n<li>Mar\u00eda Cascales Augusto (vocal)<\/li>\n<li>Eldiberto Fernandez Alvarez (vocal)<\/li>\n<li>Mar\u00eda Font Arellano (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Isidro Merino Fernandez Debido a la gran cantidad de inhibidores de la transcriptasa inversa del vih-1 con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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