{"id":94086,"date":"2018-03-11T10:13:41","date_gmt":"2018-03-11T10:13:41","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/anotacion-y-prediccion-de-residuos-funcionales-basada-en-informacion-estructural-de-protea%c2%adnas\/"},"modified":"2018-03-11T10:13:41","modified_gmt":"2018-03-11T10:13:41","slug":"anotacion-y-prediccion-de-residuos-funcionales-basada-en-informacion-estructural-de-protea%c2%adnas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/anotacion-y-prediccion-de-residuos-funcionales-basada-en-informacion-estructural-de-protea%c2%adnas\/","title":{"rendered":"Anotaci\u00f3n y predicci\u00f3n de residuos funcionales basada en informaci\u00f3n estructural de prote\u00ednas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gonzalo Lopez Garcia <\/strong><\/h2>\n<p>El virus respiratorio sincitial humano (vrsh) es un paramixovirus responsable de infecciones graves del tracto respiratorio inferior en ni\u00f1os de corta edad, inmunodeprimidos y ancianos, produciendo bronquiolitis y neumon\u00edas. Actualmente no existe vacuna eficaz contra el virus, aunque la administraci\u00f3n de anticuerpos neutralizantes en pacientes de alto riesgo representa una medida efectiva de inmunoprofilaxis. La prote\u00edna de fusi\u00f3n (f) es la principal diana antig\u00e9nica para el desarrollo de vacunas y f\u00e1rmacos ya que media la entrada del virus a la c\u00e9lula e induce anticuerpos altamente neutralizantes.  los anticuerpos anti-f altamente neutralizantes son capaces de reconocer ep\u00edtopos de la prote\u00edna f antes de que se active para iniciar el proceso de fusi\u00f3n de membranas. Por el contrario, p\u00e9ptidos sint\u00e9ticos que reproducen ciertas regiones de la prote\u00edna f o compuestos sint\u00e9ticos dirigidos contra esta prote\u00edna act\u00faan despu\u00e9s de que el virus entre en contacto con la c\u00e9lula y, por tanto, la prote\u00edna f ya se haya activado. Los fragmentos fab de anticuerpos altamente neutralizantes son capaces de inhibir la infectividad viral, lo que sugiere que su mecanismo de neutralizaci\u00f3n implica interacciones con regiones espec\u00edficas de la prote\u00edna que inhiben su activaci\u00f3n.  se han obtenido anticuerpos policlonales dirigidos contra la prote\u00edna f del vrsh tras la inoculaci\u00f3n de conejos con un virus vaccinia recombinante que expresa dicha prote\u00edna. Estos anticuerpos han resultado ser especialmente \u00fatiles para la identificaci\u00f3n de una conformaci\u00f3n de la prote\u00edna f que difiere de la que adopta esta prote\u00edna cuando se expresa en forma soluble, desprovista de las regiones transmembranal y citoplasm\u00e1tica (ftm-). Los resultados obtenidos indican que hay anticuerpos neutralizantes que no reconocen a la prote\u00edna ftm- y, sin embargo, reconocen a otra conformaci\u00f3n de la prote\u00edna que est\u00e1 presente en la superficie de c\u00e9lulas infectadas y que es menos termoestable que la prote\u00edna ftm-.  los resultados presentados en esta tesis ofrecen la posibilidad de buscar nuevos anticuerpos dirigidos frente a ep\u00edtopos implicados en neutralizaci\u00f3n, que puedan utilizarse para el tratamiento profil\u00e1ctico y\/o terap\u00e9utico de las infecciones por el vrsh.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Anotaci\u00f3n y predicci\u00f3n de residuos funcionales basada en informaci\u00f3n estructural de prote\u00ednas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Anotaci\u00f3n y predicci\u00f3n de residuos funcionales basada en informaci\u00f3n estructural de prote\u00ednas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gonzalo Lopez Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/06\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Melero Fondevilla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis EnJuan es sanchez <\/li>\n<li>Juan Ortin monton (vocal)<\/li>\n<li>Juan  Carlos S\u00e1iz calahorra (vocal)<\/li>\n<li>enrique Villar ledesma (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gonzalo Lopez Garcia El virus respiratorio sincitial humano (vrsh) es un paramixovirus responsable de infecciones graves del 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