{"id":9410,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/estudio-farmacologico-de-nuevos-antipsicoticos-potenciales-con-afinidad-hacia-los-receptores-opioides-sigma\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"estudio-farmacologico-de-nuevos-antipsicoticos-potenciales-con-afinidad-hacia-los-receptores-opioides-sigma","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-farmacologico-de-nuevos-antipsicoticos-potenciales-con-afinidad-hacia-los-receptores-opioides-sigma\/","title":{"rendered":"Estudio farmacologico de nuevos antipsicoticos potenciales con afinidad hacia los receptores opioides sigma."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rafael Monta\u00f1es Gallardo <\/strong><\/h2>\n<p>Los incovenientes asociados al uso de los antipsicoticos convencionales han impulsado el desarrollo de nuevos compuestos (p.Ej. Los antagonistas de los receptores opioides sigma), que amplien el espectro terapeutico existente. El presente trabajo consistio en un estudio farmacologico de nuevos compuestos con potencialidad antipsicotica, muchos de los cuales se relacionan estructuralmente con antagonistas sigma como el bmy-14802 o el haloperidol. El trabajo se inicio con un screening preliminar que incluia estudios de fijacion a receptores sigma, d2, 5-ht2a, y 5-ht1a, asi como el empleo de algunos modelos conductuales tipicos en la valoracion de actividad antipsicotica (antagonismo a la apomorfina). A continuacion se estudiaron los cambios bioquimicos sobre sistemas dopaminergicos y serotonergicos centrales tras administracion aguda de los compuestos en estudio. Entre los compuestos mas activos destacamos el fi-8160, fi-8168 y fi-8313. Estudios conductuales adicionales (antagonismo a la anfetamina, catalepsia, antagonismo a la mescalina, conducta de evitacion condicionada) confirmaron el interesante perfil antipsicotico de estos tres compuestos, los cuales, a su vez, potenciaron los efectos inducidos por haloperidol sobre el recambio de dopamina y la conducta de evitacion.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacologico de nuevos antipsicoticos potenciales con afinidad hacia los receptores opioides sigma.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacologico de nuevos antipsicoticos potenciales con afinidad hacia los receptores opioides sigma. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rafael Monta\u00f1es Gallardo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joaquin Del Rio Zambrana<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Florez Beledo <\/li>\n<li>Berta Esperanza Lasheras Aldaz (vocal)<\/li>\n<li>Daniel Fos Galve (vocal)<\/li>\n<li> Lopez De Ceballos Lafargas Mar\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rafael Monta\u00f1es Gallardo Los incovenientes asociados al uso de los antipsicoticos convencionales han impulsado el desarrollo de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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