{"id":9420,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/estudio-anatomopatologico-del-efecto-cardiorreparador-del-quinapril-en-ratas-espontaneamente-hipertensas-con-hipertrofia-ventricular-izquierda\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"estudio-anatomopatologico-del-efecto-cardiorreparador-del-quinapril-en-ratas-espontaneamente-hipertensas-con-hipertrofia-ventricular-izquierda","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-anatomopatologico-del-efecto-cardiorreparador-del-quinapril-en-ratas-espontaneamente-hipertensas-con-hipertrofia-ventricular-izquierda\/","title":{"rendered":"Estudio anatomopatologico del efecto cardiorreparador del quinapril en ratas espontaneamente hipertensas con hipertrofia ventricular izquierda."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Angel Panizo Santos <\/strong><\/h2>\n<p>En la hipertension arterial, el remodelado estructural del miocardio representa el punto clave de la hipertrofia patologica, la cual va a originar la disfuncion ventricular. El remodelado hipertensivo del miocardio afecta a los tres compartimentos del corazon:  cardiomiocitos, intersticio y vasos.  para evaluar y estudiar el efecto sobre el remodelado miocardico hipertensivo, hemos empleado un inhibidor de la enzima de conversion de angiotensina (ieca), quinapril, en ratas espontaneamente hipertensas (shr) con hipertrofia ventricular izquierda establecida. Tratamos durante 20 semanas 15 ratas shr de 16 semanas de edad con una dosis media 10 mg\/kg\/dia). Se estudio el compartimento miocitario mediante morfometria y citometria de flujo, la fibrosis intersticial mediante morfometria, determinacion de hidroxiprolina y estudio inmunohistoquimico, y la densidad de mastocitos en el intersticio del ventriculo izquierdo. La actividad de la eca cardiaca se evaluo mediante espectrofotometria. Se estudio asi mismo la morfolog\u00eda, morfometria y presencia de pcnaciclina y proteina myc en las arterias coronariuas intramiocardicas.  tras 20 semanas de tratamiento, se produce una disminucion de la presion arterial en shr hasta niveles similares a los observados en ratas control normotensas wistar-kyoto. Las ratas shr sin tratamiento muestran hipertrofia y poliploidizacion de los cardiomiocitos; este fenomeno es revertido tras tratamiento con quinapril. En el intersticio de shr se observa un acumulo de proteinas de matriz extracelular. Este remodelado intersticial es reparado con el tratamiento con quinapril. Hay un aumento del numero de mastocitos en el intersticio, que se correlaciona con la fibrosis intersticial. Tras tratamiento con quinapril se observa una disminucion del numero de mastocitos intersticiales en shr. Las arterias coronarias de shr no tratadas presentan un engrosamiento de su pared e hiperplasia del musculo liso. El quinapril r<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio anatomopatologico del efecto cardiorreparador del quinapril en ratas espontaneamente hipertensas con hipertrofia ventricular izquierda.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio anatomopatologico del efecto cardiorreparador del quinapril en ratas espontaneamente hipertensas con hipertrofia ventricular izquierda. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Angel Panizo Santos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier Pardo Mind\u00e1n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Diego Mart\u00ednez Caro <\/li>\n<li>Sergio Serrano Figueras (vocal)<\/li>\n<li>Pedro Errasti Goenaga (vocal)<\/li>\n<li>Asumpta Munnel Torras (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Angel Panizo Santos En la hipertension arterial, el remodelado estructural del miocardio representa el punto clave de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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