{"id":94209,"date":"2018-03-11T10:13:50","date_gmt":"2018-03-11T10:13:50","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/impacto-de-la-esteatosis-del-donante-en-la-supervivencia-global-y-recurrencia-viral-tras-trasplante-hepatico-debido-a-cirrosis-por-virus-de-la-hepatitis-c\/"},"modified":"2018-03-11T10:13:50","modified_gmt":"2018-03-11T10:13:50","slug":"impacto-de-la-esteatosis-del-donante-en-la-supervivencia-global-y-recurrencia-viral-tras-trasplante-hepatico-debido-a-cirrosis-por-virus-de-la-hepatitis-c","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cirugia-de-trasplantes\/impacto-de-la-esteatosis-del-donante-en-la-supervivencia-global-y-recurrencia-viral-tras-trasplante-hepatico-debido-a-cirrosis-por-virus-de-la-hepatitis-c\/","title":{"rendered":"Impacto de la esteatosis del donante en la supervivencia global y recurrencia viral tras trasplante hepatico debido a cirrosis por virus de la hepatitis c"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ruben Fernando Ciria Bru <\/strong><\/h2>\n<p>No existen conclusiones firmes acerca de la influencia que un \u00f3rgano esteat\u00f3sico ejerce sobre un trasplante por virus de la hepatitis c respecto a supervivencia del injerto y grado de recurrencia viral postrasplante. pacientes y metodos: se han incluido 120 trasplantes consecutivos por cirrosis debida a vhc. El grado de esteatosis fue catalogado en: no esteatosis (0-10%; n=40; 33%), leve (10-30%; n=32; 26,9%), moderada (30-60%; n=29; 24,4%) y severa (>60%; n=19; 16%). Se analizaron, sin obtenerse diferencias, las caracter\u00edsticas entre los distintos grupos de sexo, edad, tiempo de isquemia fr\u00eda y meld del receptor. La supervivencia del injerto se analiz\u00f3 con el test de kaplan meier (test exacto log rank). La recurrencia viral fue medida en periodos de 3 meses tras el trasplante y detectada mediante niveles elevados de transaminasas, biopsia y\/o pcr de rna-vhc. Las proporciones de recurrencia para cada categor\u00eda de esteatosis fueron comparadas (correcci\u00f3n de bonferroni). resultados: 56 injertos se perdieron (46%) durante el periodo de seguimiento. La supervivencia de los injertos disminuy\u00f3 con el incremento de la esteatosis de los injertos donantes: 82%, 72% y 72% a 1, 2 y 3 a\u00f1os tras el trasplante con injerto no esteat\u00f3sico; 73%, 63% y 58% respectivamente con esteatosis leve; 74%, 62% y 43% respectivamente si la esteatosis fue moderada; y 62%, 49% y 42%, respectivamente, con esteatosis severa (chi-square=5.793; p=0.012). La recurrencia viral fue m\u00e1s precoz y m\u00e1s frecuente en receptores de injertos con esteatosis >30% (46% vs 32% a 3 meses, p=0.017; 58% vs 43% a 6 meses, p=0.020; 70% vs 56% a 12 meses, p=0.05; y 95% vs 69% a los 3 a\u00f1os postrasplante, p=0.0001). conclusiones: la recurrencia de hepatitis c fue m\u00e1s frecuente y m\u00e1s precoz en receptores de \u00f3rganos con esteatosis moderada y severa y contribuye a una menor supervivencia del injerto con elevado contenido graso. El trasplante con injertos que presenten una esteatosis >30% deber\u00eda ser restringido en receptores con vhc.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Impacto de la esteatosis del donante en la supervivencia global y recurrencia viral tras trasplante hepatico debido a cirrosis por virus de la hepatitis c<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Impacto de la esteatosis del donante en la supervivencia global y recurrencia viral tras trasplante hepatico debido a cirrosis por virus de la hepatitis c <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ruben Fernando Ciria Bru <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/06\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco J. Brice\u00f1o Delgado<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Pera madrazo <\/li>\n<li>evaristo Varo p\u00e9rez (vocal)<\/li>\n<li>guillermo Solorzano peck (vocal)<\/li>\n<li>Miguel angel Suarez mu\u00f1oz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ruben Fernando Ciria Bru No existen conclusiones firmes acerca de la influencia que un \u00f3rgano esteat\u00f3sico ejerce [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[387,10,973,491],"tags":[2043,43888,39184,71501,24877,194267],"class_list":["post-94209","post","type-post","status-publish","format-standard","hentry","category-cirugia-abdominal","category-cirugia-de-trasplantes","category-cordoba","category-gastroenterologia","tag-carlos-pera-madrazo","tag-evaristo-varo-perez","tag-francisco-j-briceno-delgado","tag-guillermo-solorzano-peck","tag-miguel-angel-suarez-munoz","tag-ruben-fernando-ciria-bru"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/94209","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=94209"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/94209\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=94209"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=94209"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=94209"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}