{"id":94417,"date":"2018-03-11T10:14:06","date_gmt":"2018-03-11T10:14:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-herramientas-para-analisis-de-biomoleculas-mediante-espectrometria-de-masas-maldi-tof\/"},"modified":"2018-03-11T10:14:06","modified_gmt":"2018-03-11T10:14:06","slug":"desarrollo-de-herramientas-para-analisis-de-biomoleculas-mediante-espectrometria-de-masas-maldi-tof","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/analisis-bioquimico\/desarrollo-de-herramientas-para-analisis-de-biomoleculas-mediante-espectrometria-de-masas-maldi-tof\/","title":{"rendered":"Desarrollo de herramientas para analisis de biomoleculas mediante espectrometria de masas maldi-tof"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Egoitz Astigarraga Arribas <\/strong><\/h2>\n<p>En el presente trabajo se han desarrollado una serie de t\u00e9cnicas de preparaci\u00f3n de muestra y an\u00e1lisis mediante espectrometr\u00eda de masas maldi-tof. El desarrollo de las distintas metodolog\u00edas ha requerido de un enfoque interdisciplinar que ha podido llevarse a cabo gracias a la colaboraci\u00f3n de distintos grupos de investigaci\u00f3n. se han puesto a punto diversas t\u00e9cnicas de preparaci\u00f3n de muestra para la detecci\u00f3n mediante espectrometr\u00eda maldi-tof de distintos tipos de biomol\u00e9culas: adn, p\u00e9ptidos, prote\u00ednas, metabolitos, l\u00edpidos. en el campo de la metabol\u00f3mica se ha conseguido detectar ampc en ausencia de matriz, empleando bien desorci\u00f3n en silicio poroso o bien nanotubos de carbono en un proceso de dos etapas (purificaci\u00f3n y espectrometr\u00eda de masas). en el \u00e1rea de la lipid\u00f3mica, gracias al empleo del mbt como matriz ha sido posible detectar una amplia variedad de l\u00edpidos, tanto en extractos biol\u00f3gicos como en tejidos, incluyendo especies no detectadas en trabajos publicados previamente empleando otras matrices. por otro lado, en el presente trabajo ha sido fundamental el empleo de diversas t\u00e9cnicas estad\u00edsticas y matem\u00e1ticas tales como mapa de covarianza, calibrado polinomial y elaboraci\u00f3n y b\u00fasquedas en base de datos, implement\u00e1ndose los correspondientes algoritmos en los lenguajes de programaci\u00f3n mathematica y visual basic. Dichas herramientas se han aplicado con \u00e9xito en la caracterizaci\u00f3n de perfiles proteicos de membranas tipo raft, en la caracterizaci\u00f3n de prote\u00ednas con dominios cbs y en la determinaci\u00f3n de la composici\u00f3n lip\u00eddica en distintos extractos y tejidos. Para la t\u00e9cnica de imaging mass spectrometry se ha desarrollado un software (histomass) en colaboraci\u00f3n con la empresa de bioinform\u00e1tica noraybio, orientado espec\u00edficamente a la elaboraci\u00f3n y tratamiento de im\u00e1genes mediante espectrometr\u00eda malditof.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo de herramientas para analisis de biomoleculas mediante espectrometria de masas maldi-tof<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo de herramientas para analisis de biomoleculas mediante espectrometria de masas maldi-tof <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Egoitz Astigarraga Arribas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/06\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Andres Fernandez Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: felix Mar\u00eda Go\u00f1i urcelay <\/li>\n<li>bruno Martinez haya (vocal)<\/li>\n<li>Luis Ba\u00f1ares morcillo (vocal)<\/li>\n<li>Luis alfonso Martinez de la cruz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Egoitz Astigarraga Arribas En el presente trabajo se han desarrollado una serie de t\u00e9cnicas de preparaci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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