{"id":9453,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/estudio-experimental-en-ratas-sobre-la-cicatrizacion\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"estudio-experimental-en-ratas-sobre-la-cicatrizacion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-experimental-en-ratas-sobre-la-cicatrizacion\/","title":{"rendered":"Estudio experimental en ratas sobre la cicatrizacion."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Santamaria Robredo Ana Belen <\/strong><\/h2>\n<p>Preocupados por la repercusion que las alteraciones de la cicatrizacion (diabetes (dm) e inmunosupresion con corticoides (gc) tienen en la practica clinica, nos propusimos valorar experimentalmente si la aplicacion de factores de crecimiento (fcs) acelerarian la misma.Se tomaron 778 ratas wistar macho, a las que se les indujo un estado de dm experimental (20 mg\/kg de estreptozotocina, im) y\/o inmunosupresion (12 mg\/ kg de 6-metil-prednisolona, sc). Se les aplico igf-i (2 microg, sc) y\/o pdgf -bb (3 microg, sc) al tiempo de realizacion del tratamiento quirurgico.  los resultados obtenidos son los siguientes:  supervivencia: ratas tratadas con gc tienen una mayor supervivencia, disminuyendo esta tras la aplicacion de ecs.  en ratas no diabeticas sin corticoides, solo pdgf aumento la supervivencia, mientras que igf fue la mas activa en ratas diabeticas sin corticoides.  fase catabolica: los fcs no mejoran la inhibicion de esta fase producida por dm o gc.  fase anabolica: los gc(12 mg\/kg de 6-metil-prednisolona sc), aumentan el contenido del tejido de granulacion comparado con el grupo control.  en ratas no diabeticas con corticoides, solo pdgf estimula dicha fase: en ratas diabeticas sin corticoides, es igf.  contraccion: la combinacion igf-pdgf no mejoro ninguna de las fases, a excepcion de la contraccion en ratas diabeticas con corticoides y no diabeticas sin corticoides. En ratas diabeticas sin corticoides y no diabeticas con corticoides, pdgf es mas efectiva.  concluimos que los fcs mejoran la cicatrizacion de las heridas en estados deficitarios, pudiendo actuar especificamente sobre la fase comprometida con el factor adecuado para el caso.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio experimental en ratas sobre la cicatrizacion.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio experimental en ratas sobre la cicatrizacion. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Santamaria Robredo Ana Belen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier Pardo Mind\u00e1n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mat\u00edas Jurado Chac\u00f3n <\/li>\n<li>Angel Dominguez Casares (vocal)<\/li>\n<li>Sergio Serrano Figueras (vocal)<\/li>\n<li>Leoncio Bento Bravo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Santamaria Robredo Ana Belen Preocupados por la repercusion que las alteraciones de la cicatrizacion (diabetes (dm) e [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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