{"id":94581,"date":"2018-03-11T10:14:18","date_gmt":"2018-03-11T10:14:18","guid":{"rendered":""},"modified":"2018-03-11T10:14:18","modified_gmt":"2018-03-11T10:14:18","slug":"el-tratamiento-antiviral-con-interferon-pegilado-y-ribavirina-reduce-el-gradiente-de-presion-venosa-hepatica-en-pacientes-con-hepatitis-cronica-por-el-virus-c-fibrosis-avanzada-o-cirrosis-e-hipertens","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-tratamiento-antiviral-con-interferon-pegilado-y-ribavirina-reduce-el-gradiente-de-presion-venosa-hepatica-en-pacientes-con-hepatitis-cronica-por-el-virus-c-fibrosis-avanzada-o-cirrosis-e-hipertens\/","title":{"rendered":"El tratamiento antiviral con interfer\u00f3n pegilado y ribavirina reduce el gradiente de presi\u00f3n venosa hep\u00e1tica en pacientes con hepatitis cr\u00f3nica por el virus c, fibrosis avanzada o cirrosis e hipertensi\u00f3n portal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Diego Rinc\u00f3n Rodr\u00edguez <\/strong><\/h2>\n<p>La hepatitis cr\u00f3nica por el virus c ocasiona cirrosis hep\u00e1tica en un 30  de los casos. La mayor\u00eda de los pacientes con cirrosis desarrollan hipertensi\u00f3n portal (htp), que se encuentra en la base de las m\u00e1s importantes complicaciones de dicha enfermed ad. La reducci\u00f3n en el grado de htp conlleva una mejor\u00eda del pron\u00f3stico de la cirrosis hep\u00e1tica. El tratamiento antiviral de la hepatitis c ha demostrado su capacidad para mejorar las lesiones hep\u00e1ticas secundarias a la hepatitis. Sin embargo, se des conoce su efecto sobre el s\u00edndrome de htp. El objetivo del trabajo fue evaluar el efecto del tratamiento con interfer\u00f3n pegilado alfa2b y ribavirina sobre el grado de htp en pacientes con cirrosis hep\u00e1tica compensada secundaria a hepatitis cr\u00f3nica c.  Para ello, se realizaron cateterismos de venas suprahep\u00e1ticas para medici\u00f3n del gradiente de presi\u00f3n venosa hep\u00e1tica (gpvh, capaz de estimar fiablemente el grado de htp) inmediatamente antes y despu\u00e9s del tratamiento antiviral, realizado en funci\u00f3n de los protocoles habituales. Se demostr\u00f3 la obtenci\u00f3n de un marcado efecto beneficioso del tratamiento antiviral sobre el grado de htp (reducci\u00f3n media de un 30 ), en 19 de los 20 pacientes tratados. Se demostr\u00f3 la existencia de un mayor efecto hipo tensor en aquellos pacientes que obtuvieron respuesta virol\u00f3gica y bioqu\u00edmica. No se evidenciaron efectos adversos graves secundarios al tratamiento. Conclusi\u00f3n: el tratamiento antiviral con interfer\u00f3n pegilado y ribavirina reduce marcadamente el gra do de htp en pacientes con cirrosis y hepatitis cr\u00f3nica c.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El tratamiento antiviral con interfer\u00f3n pegilado y ribavirina reduce el gradiente de presi\u00f3n venosa hep\u00e1tica en pacientes con hepatitis cr\u00f3nica por el virus c, fibrosis avanzada o cirrosis e hipertensi\u00f3n portal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El tratamiento antiviral con interfer\u00f3n pegilado y ribavirina reduce el gradiente de presi\u00f3n venosa hep\u00e1tica en pacientes con hepatitis cr\u00f3nica por el virus c, fibrosis avanzada o cirrosis e hipertensi\u00f3n portal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Diego Rinc\u00f3n Rodr\u00edguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/06\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Ba\u00f1ares Ca\u00f1izares<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Millan nu\u00f1ez cortes <\/li>\n<li>ricardo Moreno otero (vocal)<\/li>\n<li>conrado Fern\u00e1ndez rodr\u00edguez (vocal)<\/li>\n<li>agust\u00edn Albillos mart\u00ednez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Diego Rinc\u00f3n Rodr\u00edguez La hepatitis cr\u00f3nica por el virus c ocasiona cirrosis hep\u00e1tica en un 30 de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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