{"id":94626,"date":"2018-03-11T10:14:23","date_gmt":"2018-03-11T10:14:23","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-nutrigenetico-sobre-la-influencia-de-la-dieta-mediterranea-en-la-adiposidad-corporal-de-una-poblacion-con-alto-riesgo-cardiovascular\/"},"modified":"2018-03-11T10:14:23","modified_gmt":"2018-03-11T10:14:23","slug":"estudio-nutrigenetico-sobre-la-influencia-de-la-dieta-mediterranea-en-la-adiposidad-corporal-de-una-poblacion-con-alto-riesgo-cardiovascular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/genetica\/estudio-nutrigenetico-sobre-la-influencia-de-la-dieta-mediterranea-en-la-adiposidad-corporal-de-una-poblacion-con-alto-riesgo-cardiovascular\/","title":{"rendered":"Estudio nutrigen\u00e9tico sobre la influencia de la dieta mediterr\u00e1nea en la adiposidad corporal de una poblaci\u00f3n con alto riesgo cardiovascular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Razquin Burillo <\/strong><\/h2>\n<p>Nutrigenetics is the science that studies the response of individuals to diet component depending on their genetic background. The present project was aimed to analyze the effect of several gene variants (pro12ala of ppar\u00ed\u00a3, -174g\/c of il-6, -4034a\/c, +45t\/g and +276g\/t of adipoq and rs9939609t\/a of fto) and a mediterranean-style dietary intervention on 3-year adiposity changes of a high cardiovascular risk population. 1055 subjects at high cardiovascular risk were recruited in primary care centres of navarra. They were randomly allocated to one of the three intervention groups: the control group that followed a low fat diet, the mediterranean diet plus high intake of virgin olive oil (md+voo) and the mediterranean diet plus high intake of nuts (md+nuts). All the subjects were genotyped for the polymorphism in adiposity related genes. Moreover, after 3-year intervention, we measured the plasma total antioxidant capacity (tac) in a subsample of subjects in order to analyze the beneficial effects of the mediterranean diet. we observed that both md groups, especially the md+voo group, had higher levels plasma tac after three years of intervention. In addition, md was able to reverse the negative effect of carrying the 12ala allele of ppar\u00ed\u00a3 gene appeared to have on waist circumference change. Moreover, the rs9939609 variant of fto was associated with lower body weight gain in subjects following a md diet. Likewise, cc subjects for the -174g\/c polymorphism of il-6 gene that followed an md+voo were those with the lowest body weight gain.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio nutrigen\u00e9tico sobre la influencia de la dieta mediterr\u00e1nea en la adiposidad corporal de una poblaci\u00f3n con alto riesgo cardiovascular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio nutrigen\u00e9tico sobre la influencia de la dieta mediterr\u00e1nea en la adiposidad corporal de una poblaci\u00f3n con alto riesgo cardiovascular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Razquin Burillo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/06\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Amelia Angela Marti Del Moral<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 alfredo Martinez hernandez <\/li>\n<li>Emilio Mart\u00ednez de victoria mu\u00f1oz (vocal)<\/li>\n<li>Miguel \u00e1ngel Mart\u00ednez gonz\u00e1lez (vocal)<\/li>\n<li>Mar\u00eda  Luisa Puerta lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Razquin Burillo Nutrigenetics is the science that studies the response of individuals to diet component depending [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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