{"id":94683,"date":"2009-01-07T00:00:00","date_gmt":"2009-01-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-fase-i-con-la-combinacion-de-gemcitabina-y-doxorubicina-liposomal-pegilada-en-el-tratamiento-de-la-recurrencia-del-carcinoma-de-ovario-de-mal-pronostico\/"},"modified":"2009-01-07T00:00:00","modified_gmt":"2009-01-07T00:00:00","slug":"estudio-fase-i-con-la-combinacion-de-gemcitabina-y-doxorubicina-liposomal-pegilada-en-el-tratamiento-de-la-recurrencia-del-carcinoma-de-ovario-de-mal-pronostico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ginecologia\/estudio-fase-i-con-la-combinacion-de-gemcitabina-y-doxorubicina-liposomal-pegilada-en-el-tratamiento-de-la-recurrencia-del-carcinoma-de-ovario-de-mal-pronostico\/","title":{"rendered":"Estudio fase i con la combinaci\u00f3n de gemcitabina y doxorubicina liposomal pegilada en el tratamiento de la recurrencia del carcinoma de ovario de mal pron\u00f3stico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Guillermo Crespo Herrero <\/strong><\/h2>\n<p>El pron\u00f3stico del carcinoma de ovario viene determinado por el tiempo transcurrido desde el \u00faltimo tratamiento hasta la recurrencia de la enfermedad, siendo peor cuando el intervalo libre de enfermedad (ile) se sit\u00faa entre 6 meses y un a\u00f1o (pacientes parcialmente platino sensibles) y cuando la recurrencia sucede antes de 6 meses (pacientes platino resistentes). El tratamiento est\u00e1ndar en segunda l\u00ednea es la doxorubicina liposomal pegilada (dlp) y otras opciones posibles son el topotecan y la gemcitabina. Con la realizaci\u00f3n de este estudio fase i con la combinaci\u00f3n de dlp y gemcitabina pretendemos definir la toxicidad limitante de dosis y la m\u00e1xima dosis tolerable para determinar la dosis recomendable para la realizaci\u00f3n de un estudio fase ii con este esquema en este tipo de pacientes, as\u00ed como estudiar distintos par\u00e1metros farmacocin\u00e9ticas y farmacogen\u00e9ticos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio fase i con la combinaci\u00f3n de gemcitabina y doxorubicina liposomal pegilada en el tratamiento de la recurrencia del carcinoma de ovario de mal pron\u00f3stico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio fase i con la combinaci\u00f3n de gemcitabina y doxorubicina liposomal pegilada en el tratamiento de la recurrencia del carcinoma de ovario de mal pron\u00f3stico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Guillermo Crespo Herrero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/07\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angel Jim\u00e9nez Lacave<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco javier Ferrer barriendos <\/li>\n<li>emiliano Calvo aller (vocal)<\/li>\n<li>Antonio Casado herr\u00e1ez (vocal)<\/li>\n<li>oscar Fernandez hidalgo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Guillermo Crespo Herrero El pron\u00f3stico del carcinoma de ovario viene determinado por el tiempo transcurrido desde el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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