{"id":94715,"date":"2009-02-07T00:00:00","date_gmt":"2009-02-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/las-protea%c2%adnas-polycomb-ring1a-y-ring1b-en-la-homeostasis-de-celulas-madre-y-progenitoras\/"},"modified":"2009-02-07T00:00:00","modified_gmt":"2009-02-07T00:00:00","slug":"las-protea%c2%adnas-polycomb-ring1a-y-ring1b-en-la-homeostasis-de-celulas-madre-y-progenitoras","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/las-protea%c2%adnas-polycomb-ring1a-y-ring1b-en-la-homeostasis-de-celulas-madre-y-progenitoras\/","title":{"rendered":"Las prote\u00ednas polycomb ring1a y ring1b en la homeostasis de c\u00e9lulas madre y progenitoras"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Monica Roman Trufero <\/strong><\/h2>\n<p>Null las prote\u00ednas polycomb constituyen un sistema de regulaci\u00f3n de la expresi\u00f3n g\u00e9nica conservado en la escala evolutiva. Estas prote\u00ednas act\u00faan formando complejos asociados a lo cromatina actuando como reguladores epigen\u00e9ticos en diversos procesos del d esarrollo embrionario, como la especificaci\u00f3n del eje antero-posterior y, en general,  la determinaci\u00f3n de la identidad a celular.  \tel objetivo de este trabajo es el estudio de la funci\u00f3n de ring1b y su hom\u00f3logo ring1a, responsables de la monoubiqui tinaci\u00f3n de h2a asociada a represi\u00f3n transcripcional. Con este fin hemos utilizado una aproximaci\u00f3n gen\u00e9tica para el estudio de su funci\u00f3n en la estabilidad y diferenciaci\u00f3n de c\u00e9lulas madre espec\u00edficas de linaje en un modelo de hematopoyesis adulta y de neurog\u00e9nesis fetal.  \taqu\u00ed mostramos que durante la diferenciaci\u00f3n hematopoy\u00e9tica adulta, ring1b act\u00faa como un regulador homeost\u00e1tico, mediante el control negativo de la proliferaci\u00f3n de c\u00e9lulas progenitoras y como regulador positivo de la expan si\u00f3n de precursores maduros. Esta funci\u00f3n tiene lugar a trav\u00e9s de la represi\u00f3n de la actividad de dos reguladores antag\u00f3nicos del ciclo celularciclina d2\/ccnd2 y p16ink4a\/cdkn2a. Tambi\u00e9n mostramos que ring1a compensa parcialmente la funci\u00f3n de ring1b  en las c\u00e9lulas madre hematopoy\u00e9ticas y que conjuntamente son esenciales para el mantenimiento del compartimento hematopoy\u00e9tico. \tpor otro lado, usando un modelo de c\u00e9lulas madre neurales (cmn) de bulbo olfatorio embrionario demostramos que ring1b y ring1a son esenciales para el mantenimiento de su capacidad de autorrenovaci\u00f3n y proliferaci\u00f3n, mediante la represi\u00f3n del programa de diferenciaci\u00f3n neuronal. Al mismo tiempo, mostramos que ring1b act\u00faa como un promotor de la diferenciaci\u00f3n de cmn y en la regulaci\u00f3n en la especificaci\u00f3n de cmn con potencial diferenciativo glial.    \ten conjunto, este trabajo contribuye a la comprensi\u00f3n del control epigen\u00e9tico de la generaci\u00f3n de diversidad celular dependiente del sistema polycomb, con un \u00e9nfasis  en su funci\u00f3n en el control coordinado de la proliferaci\u00f3n celular y del uso diferencial de la informaci\u00f3n gen\u00e9tica que determina la formaci\u00f3n ordenada de  linajes celulares en el embri\u00f3n y en el adulto.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Las prote\u00ednas polycomb ring1a y ring1b en la homeostasis de c\u00e9lulas madre y progenitoras<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Las prote\u00ednas polycomb ring1a y ring1b en la homeostasis de c\u00e9lulas madre y progenitoras <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Monica Roman Trufero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/07\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Angel Vidal Caballero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ricardo Pardal redondo <\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Monica Roman Trufero Null las prote\u00ednas polycomb constituyen un sistema de regulaci\u00f3n de la expresi\u00f3n g\u00e9nica conservado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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