{"id":94782,"date":"2009-03-07T00:00:00","date_gmt":"2009-03-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-estructural-y-funcional-de-los-promotores-humanos-srebp1-y-su-regulador-insig2\/"},"modified":"2009-03-07T00:00:00","modified_gmt":"2009-03-07T00:00:00","slug":"caracterizacion-estructural-y-funcional-de-los-promotores-humanos-srebp1-y-su-regulador-insig2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/procesos-metabolicos\/caracterizacion-estructural-y-funcional-de-los-promotores-humanos-srebp1-y-su-regulador-insig2\/","title":{"rendered":"Caracterizaci\u00f3n estructural y funcional de los promotores humanos srebp1 y su regulador insig2"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Julia Fern\u00e1ndez-alvarez <\/strong><\/h2>\n<p>Las prote\u00ednas srebp son factores de transcripci\u00f3n que regulan la homeostasis lip\u00eddica. Estas prote\u00ednas son activadas por procesamiento proteolitico regulado por las prote\u00ednas scap e insig. Alteraciones en estas prote\u00ednas se han relacionado con el desarrollo del s\u00edndrome metab\u00f3lico. El objetivo de la tesis fue la caracterizaci\u00f3n a nivel estructural y funcional de la regulaci\u00f3n transcripcional de esta via,  estudiando especificamente los promotores de los genes humanos que codifican las porte\u00ednas srebp1a, srebp1c e insig2.  Se utilizaron t\u00e9cnicas de analisis tanscripcional por ensayos de luciferasa con construcciones silvestres y mutantes, ensayos de movilidad electrofor\u00e9tica (emsa), rt-pcr, pcr a tiempo real, rna de interferencia y experimentos de inmunoprecipitaci\u00f3n de cromatina (chip). De los resultados obtenidos se puede demostrar que: -el promotor srebp1a humano est\u00e1 comprendido en 75 pb que contienen 3 cajas gc que se unen a las prote\u00ednas sp1 y egr1, con acciones opuestas sobre el promotor, siendo sp1 un activador y egr1 un inhibidor de la actividad. &#8211; el promotor srebp1c humano es activado por insulina y agonistas lxr e inhibido en presencia de camp y pufas al igual que el promotor de rat\u00f3n. Adem\u00e1s es ativado por los ppars . El cofactor pgc1 es reclutado al promotor en los tratamientos con insulina y con un agonista pparalpha (wy). &#8211; en humanos a diferencia del rat\u00f3n existe una \u00fancia variante de mrna de insig2. El pormotor insig2 humano es activado por la prote\u00ednas sap1a en c\u00e9lulas de origen hep\u00e1tico y por elk1 y sap1a en c\u00e9lulas de origen renal. La prote\u00ednas sap1a debe estar fosforilada para activar al promotor y esta acci\u00f3n es independiente de srf.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n estructural y funcional de los promotores humanos srebp1 y su regulador insig2<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n estructural y funcional de los promotores humanos srebp1 y su regulador insig2 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Julia Fern\u00e1ndez-alvarez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/07\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Marta Casado Pinna<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ramon Bartrons bach <\/li>\n<li>Mar\u00eda Jos\u00e9 Mart\u00ednez d\u00edaz-guerra (vocal)<\/li>\n<li>domingo Barettino fraile (vocal)<\/li>\n<li>veronica Noe  mata (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Julia Fern\u00e1ndez-alvarez Las prote\u00ednas srebp son factores de transcripci\u00f3n que regulan la homeostasis lip\u00eddica. Estas prote\u00ednas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[115,9399,91],"tags":[195230,40184,102111,123268,33596,20222],"class_list":["post-94782","post","type-post","status-publish","format-standard","hentry","category-bioquimica-molecular","category-cultivo-celular","category-procesos-metabolicos","tag-ana-julia-fernandez-alvarez","tag-domingo-barettino-fraile","tag-maria-jose-Martinez-diaz-guerra","tag-marta-casado-pinna","tag-ramon-bartrons-bach","tag-veronica-noe-mata"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/94782","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=94782"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/94782\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=94782"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=94782"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=94782"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}