{"id":94827,"date":"2009-03-07T00:00:00","date_gmt":"2009-03-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-fisiologico-y-patologico-del-amiloide-beta\/"},"modified":"2009-03-07T00:00:00","modified_gmt":"2009-03-07T00:00:00","slug":"papel-fisiologico-y-patologico-del-amiloide-beta","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cordoba\/papel-fisiologico-y-patologico-del-amiloide-beta\/","title":{"rendered":"Papel fisiologico y patologico del amiloide beta"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pedro Manuel Rold\u00e1n Villarejo <\/strong><\/h2>\n<p>En la presente tesis doctoral se describen los efectos del amiloide beta (1-40) y del ngf, a trav\u00e9s del receptor de baja afinidad p75ntr sobre la expresi\u00f3n del gen hes1, la morfolog\u00eda dendr\u00edtica y la actividad sin\u00e1ptica inhibitoria (gaba\u00e9rgica) de las neuronas de hipocampo. El estudio de la expresi\u00f3n del gen hes1, as\u00ed como de la s\u00edntesis de la prote\u00edna que codifica (hes1), se hace mediante el uso de las t\u00e9cnicas de rt-pcr e inmunoprecipitaci\u00f3n y western-blot, mientras que los an\u00e1lisis morfol\u00f3gico y sinaptog\u00e9nico se realizan mediante inmunocitofluorescencia. Adem\u00e1s del estudio de dichas caracter\u00edsticas a tiempos determinados, seg\u00fan fueran ensayos enfocados al an\u00e1lisis molecular, morfol\u00f3gico o sinaptog\u00e9nico de la muestra, descritos para cada caso particular, tambi\u00e9n se realizaron experimentos en los que se midieron esas mismas caracter\u00edsticas (excepto el an\u00e1lisis morfol\u00f3gico) a lo largo de periodos de tiempo de no m\u00e1s de 5 horas, a intervalos de 30 minutos. tambi\u00e9n se describe una de las rutas implicadas en el control del desarrollo axonal y dendr\u00edtico de las neuronas de hipocampo, como es la v\u00eda de se\u00f1alizaci\u00f3n en la que est\u00e1 involucrada la prote\u00edna rhoa \u00absmall gtpase\u00bb, demostrando que la reducci\u00f3n que \u00e9sta ejerce sobre la complejidad dendr\u00edtica es realizada por una ruta independiente de la expresi\u00f3n de hes1.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel fisiologico y patologico del amiloide beta<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel fisiologico y patologico del amiloide beta <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pedro Manuel Rold\u00e1n Villarejo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/07\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alfredo Marino Rodriguez Tebar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Gracia navarro <\/li>\n<li>Mar\u00eda  angeles Arevalo arevalo (vocal)<\/li>\n<li>angel Manuel Carrion rodriguez (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Frade l\u00f3pez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pedro Manuel Rold\u00e1n Villarejo En la presente tesis doctoral se describen los efectos del amiloide beta (1-40) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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