{"id":94891,"date":"2009-06-07T00:00:00","date_gmt":"2009-06-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-producidas-por-la-diabetes-mellitus-en-la-regulacion-inter-e-intracelular-de-la-corriente-transitoria-de-salida-de-potasio-cardiaca\/"},"modified":"2009-06-07T00:00:00","modified_gmt":"2009-06-07T00:00:00","slug":"alteraciones-producidas-por-la-diabetes-mellitus-en-la-regulacion-inter-e-intracelular-de-la-corriente-transitoria-de-salida-de-potasio-cardiaca","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/endocrinologia\/alteraciones-producidas-por-la-diabetes-mellitus-en-la-regulacion-inter-e-intracelular-de-la-corriente-transitoria-de-salida-de-potasio-cardiaca\/","title":{"rendered":"Alteraciones producidas por la diabetes mellitus en la regulacion inter e intracelular de la corriente transitoria de salida de potasio cardiaca"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Raul Setien Trueba <\/strong><\/h2>\n<p>La diabetes mellitus provoca una disminuci\u00f3n en la amplitud de la corriente transitoria de salida de potasio, ito, pero hasta la fecha no se conoce en absoluto los mecanismos intracelulares responsables de la regulaci\u00f3n de la expresi\u00f3n de dicha corriente, ni c\u00f3mo se encuentran estos mecanismos en el coraz\u00f3n de animales diab\u00e9ticos.      en este sentido, y teniendo en cuenta que la integridad del sistema nervioso simp\u00e1tico, as\u00ed como la presencia de determinados factores tr\u00f3ficos son necesarios para una adecuada expresi\u00f3n de la corriente ito, en la presente tesis doctoral hemos estudiado, mediante la t\u00e9cnica del patch clamp, los efectos de la incubaci\u00f3n cr\u00f3nica con noradrenalina y el factor de crecimiento b\u00e1sico de los fibroblastos, fgf-2, sobre la expresi\u00f3n de la corriente ito en miocitos ventriculares de ratas diab\u00e9ticas, as\u00ed como medido el grado de fibrosis cardiaca por m\u00e9todos bioqu\u00edmicos e histoqu\u00edmicos y descrito la v\u00eda intracelular de actuaci\u00f3n de la noradrenalina.      una vez realizada la experimentaci\u00f3n se concluye que el fgf-2 no se requiere para el mantenimiento de la corriente ito en coraz\u00f3n adulto y que el grado de fibrosis en corazones diab\u00e9ticos se encuentra aumentado respecto de los sanos. Adem\u00e1s, una adecuada estimulaci\u00f3n simp\u00e1tica basal es necesaria para el mantenimiento de la expresi\u00f3n de la corriente ito. Esta estimulaci\u00f3n llevada a cabo por la noradrenalina est\u00e1 mediada por receptores beta adren\u00e9rgicos capaces de activar una v\u00eda intracelular en la que participan  prote\u00ednas gs, gi, adenilato ciclasa,  pka y la internalizaci\u00f3n del propio receptor, siendo la activaci\u00f3n de las mapks erk1\/2 el mecanismo final responsable del aumento de la expresi\u00f3n de la corriente ito en miocitos cardiacos de animales diab\u00e9ticos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones producidas por la diabetes mellitus en la regulacion inter e intracelular de la corriente transitoria de salida de potasio cardiaca<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones producidas por la diabetes mellitus en la regulacion inter e intracelular de la corriente transitoria de salida de potasio cardiaca <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Raul Setien Trueba <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/07\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Oscar Casis Saenz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eduardo Arilla ferreiro <\/li>\n<li>teresa Perez garcia (vocal)<\/li>\n<li>Jes\u00fas Hernandez cascales (vocal)<\/li>\n<li>ramon Lopez lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Raul Setien Trueba La diabetes mellitus provoca una disminuci\u00f3n en la amplitud de la corriente transitoria de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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