{"id":94892,"date":"2009-06-07T00:00:00","date_gmt":"2009-06-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-de-la-gtpasa-rac1-en-la-senalizacion-y-muerte-celular-mediada-por-el-peptido-1-42-beta-amiloide\/"},"modified":"2009-06-07T00:00:00","modified_gmt":"2009-06-07T00:00:00","slug":"implicacion-de-la-gtpasa-rac1-en-la-senalizacion-y-muerte-celular-mediada-por-el-peptido-1-42-beta-amiloide","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/implicacion-de-la-gtpasa-rac1-en-la-senalizacion-y-muerte-celular-mediada-por-el-peptido-1-42-beta-amiloide\/","title":{"rendered":"Implicacion de la gtpasa rac1 en la se\u00f1alizacion y muerte celular mediada por el peptido 1-42 beta-amiloide"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Miriam Hernando Rodriguez <\/strong><\/h2>\n<p>Las gtpasas monom\u00e9ricas, junto con sus mol\u00e9culas reguladoras y efectoras, participan como elementos de control esenciales en rutas de se\u00f1alizaci\u00f3n que intervienen en pr\u00e1cticamente la totalidad de los procesos que regulan la fisiolog\u00eda celular. Estas mol\u00e9culas funcionan como interruptores moleculares a nivel de la se\u00f1alizaci\u00f3n celular. Se presentan en dos conformaciones, una conformaci\u00f3n inactiva, cuando estan cargadas con gdp y una conformaci\u00f3n activa cuando estan cargadas con gtp y son reguladas por factores intercambiadores, (gefs), prote\u00ednas activadoras de las gtpasas (gaps) y por inhibidores de la disociaci\u00f3n de nucle\u00f3tidos de guanina (gdis).  estas gtpasas constituyen por tanto, uno de los elementos centrales en las complejas regulaciones de los procesos de se\u00f1alizaci\u00f3n celular y est\u00e1n especializadas en diferentes funciones dependiendo de las familias. As\u00ed, los miembros de la familia rho, entre los que destacan rho, rac1 y cdc42, regulan procesos fisiol\u00f3gicos como son los cambios en el citoesqueleto de actina, proliferaci\u00f3n, diferenciaci\u00f3n celular y apoptosis. Debido a la importancia de las funciones que desempa\u00f1an estas gtpasas, su desregulaci\u00f3n puede producir trastornos en la fisiolog\u00eda celular que en muchos de los casos acaban con enfermedades muy graves o con la muerte del organismo.  el presente trabajo se ha centrado en el estudio de la implicaci\u00f3n de la gtpasa rac1 en la se\u00f1alizaci\u00f3n y muerte neuronal inducida por el p\u00e9ptido \u00edY-amiloide, el factor neurot\u00f3xico primario en la patogenia de la enfermedad de alzheimer.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicacion de la gtpasa rac1 en la se\u00f1alizacion y muerte celular mediada por el peptido 1-42 beta-amiloide<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicacion de la gtpasa rac1 en la se\u00f1alizacion y muerte celular mediada por el peptido 1-42 beta-amiloide <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Miriam Hernando Rodriguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/07\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Zugaza Gurruchaga<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Matute almau <\/li>\n<li>Mar\u00eda   Jos\u00e9 Caloca roldan (vocal)<\/li>\n<li>valent\u00edn Ce\u00f1a callejo (vocal)<\/li>\n<li>Marta Couce matovelle (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Miriam Hernando Rodriguez Las gtpasas monom\u00e9ricas, junto con sus mol\u00e9culas reguladoras y efectoras, participan como elementos de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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