{"id":95009,"date":"2009-09-07T00:00:00","date_gmt":"2009-09-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/n-heteroarilaminidas-de-piridinio-preparacion-de-aminas-y-poliaminas-ramificadas\/"},"modified":"2009-09-07T00:00:00","modified_gmt":"2009-09-07T00:00:00","slug":"n-heteroarilaminidas-de-piridinio-preparacion-de-aminas-y-poliaminas-ramificadas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/compuestos-heterociclicos\/n-heteroarilaminidas-de-piridinio-preparacion-de-aminas-y-poliaminas-ramificadas\/","title":{"rendered":"N-heteroarilaminidas de piridinio: preparaci\u00f3n de aminas y poliaminas ramificadas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rafael Castillo Romero <\/strong><\/h2>\n<p>Las n-heteroarilaminidas de piridinio han demostrado ser unos materiales de partida competitivos para la s\u00edntesis de compuestos heteroc\u00edclicos, debido a la gran variedad reacciones que se pueden llevar a cabo sobre ellas de manera regioselectiva. En el presente trabajo de investigaci\u00f3n se enfoca la utilidad de diferentes n-azinilaminidas de piridinio halogenadas para la preparaci\u00f3n de aminoazinas con elevada funcionalizaci\u00f3n.  el trabajo se centra fundamentalmente en poner a punto un m\u00e9todo de s\u00edntesis regioselectiva de 2-aminopirazinas 3,5-disustituidas y en prepararar  poli-heteroarilaminas a partir de n-heteroarilaminidas de piridinio y sustratos poli-halogenados para finalmente explorar la posibilidad de obtener poliaminas ramificadas o dendrim\u00e9ricas.   en el esquema siguiente se resume la s\u00edntesis de las 2-aminopirazinas a partir de la 3,5-dibromopirazinilaminida de piridinio en la que est\u00e1n implicados procesos de arilaci\u00f3n mediados por paladio (reacci\u00f3n de suzuki), alquilaci\u00f3n y reducci\u00f3n sucesivamente y donde dos de ellos trascurren con una elevada regioselectividad:      a partir de diversas n-heteroarilaminidas de piridinio adecuadamente funcionalizadas y derivados polihalogendos, empleado procesos an\u00e1logos de alquilaci\u00f3n regioselectiva se ha logrado la s\u00edntesis de polisales con las estructuras que se muestran a continuaci\u00f3n:   el enlace n-n de estas sales se reduce satisfactoriamente originando las siguientes poliaminas ramificadas:    finalmente, se ha estudiado la viabilidad de aplicar estos procesos a la s\u00edntesis de estructuras de mayor complejidad y de naturaleza dendrim\u00e9rica, logr\u00e1ndose la preparaci\u00f3n de hexa-sales ramificadas sobre las que llevar a cabo procesos de reducci\u00f3n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>N-heteroarilaminidas de piridinio: preparaci\u00f3n de aminas y poliaminas ramificadas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 N-heteroarilaminidas de piridinio: preparaci\u00f3n de aminas y poliaminas ramificadas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rafael Castillo Romero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/07\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>builla G\u00f3mez \u00e1lvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  jos\u00e9 Vaquero l\u00f3pez <\/li>\n<li>Antonio Herrera fern\u00e1ndez (vocal)<\/li>\n<li>joaquin Plumet ortega (vocal)<\/li>\n<li>Jos\u00e9 Miguel M\u00ednguez ortega (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rafael Castillo Romero Las n-heteroarilaminidas de piridinio han demostrado ser unos materiales de partida competitivos para la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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