{"id":95076,"date":"2009-10-07T00:00:00","date_gmt":"2009-10-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-del-homologo-de-ku70-en-candida-albicans-analisis-de-la-funcion-de-la-protea%c2%adna-en-el-mantenimiento-de-los-telomeros\/"},"modified":"2009-10-07T00:00:00","modified_gmt":"2009-10-07T00:00:00","slug":"caracterizacion-del-homologo-de-ku70-en-candida-albicans-analisis-de-la-funcion-de-la-protea%c2%adna-en-el-mantenimiento-de-los-telomeros","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/extremadura\/caracterizacion-del-homologo-de-ku70-en-candida-albicans-analisis-de-la-funcion-de-la-protea%c2%adna-en-el-mantenimiento-de-los-telomeros\/","title":{"rendered":"Caracterizaci\u00f3n del hom\u00f3logo de ku70 en candida albicans. an\u00e1lisis de la funci\u00f3n de la prote\u00edna en el mantenimiento de los tel\u00f3meros."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Lidia Chico Dom\u00ednguez <\/strong><\/h2>\n<p>El complejo ku participa en procesos de reparaci\u00f3n de da\u00f1os en el dna y de regulaci\u00f3n de los tel\u00f3meros en una gran variedad de organimos. En este trabajo, hemos analizamos la funci\u00f3n de la prote\u00edna ku70 en el hongo pat\u00f3geno diploide candida albicans.  hemos observado sensibilidad en los mutantes heterocig\u00f3ticos y homocig\u00f3ticos ku70 tanto a altas temperaturas como al agente mutag\u00e9nico mms. En la regulaci\u00f3n de la longitud de tel\u00f3meros, la situaci\u00f3n de c. Albicans es sorprendente ya que se observaron efectos complejos dependientes de dosis g\u00e9nica. Mientras que los mutantes heterocig\u00f3ticos ku70\/ku70 exhibieron tel\u00f3meros cortos, el mutante nulo ku70 mostr\u00f3 tel\u00f3meros largos y heterog\u00e9neos. Por otro lado, el an\u00e1lisis de diversas combinaciones de mutantes sugiri\u00f3 que la elongaci\u00f3n de los tel\u00f3meros en los mutantes nulos ku70 se debe principalmente a una acci\u00f3n incontrolada de la telomerasa. Adem\u00e1s, la ausencia de ku70 provoc\u00f3 la aparici\u00f3n de altos niveles de estructuras telom\u00e9ricas circulares extracromosomales mediante la activaci\u00f3n de una recombinaci\u00f3n telom\u00e9rica aberrante. Finalmente, se demostr\u00f3 que tanto la subunidad ku70 como ku80, pertenecientes al complejo ku, est\u00e1n asociadas al rna molde de la telomerasa (ter1). Esta asociaci\u00f3n es consistente con la implicaci\u00f3n de ku70 en la adici\u00f3n de tel\u00f3meros de novo.  en conjunto, nuestras observaciones apuntan a m\u00faltiples funciones del complejo ku en la regulaci\u00f3n y protecci\u00f3n de los tel\u00f3meros en c. Albicans. En particular, varios de los fenotipos observados en mutantes ku70 no pudieron ser totalmente revertidos al reintegrarse el alelo perdido. Dada la implicaci\u00f3n de ku70 en el mantenimiento de los tel\u00f3meros, la no reversi\u00f3n podr\u00eda ser causada por cambios epigen\u00e9ticos en la heterocromatina tel\u00f3merica en ausencia de dicha prote\u00edna.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n del hom\u00f3logo de ku70 en candida albicans. an\u00e1lisis de la funci\u00f3n de la prote\u00edna en el mantenimiento de los tel\u00f3meros.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n del hom\u00f3logo de ku70 en candida albicans. an\u00e1lisis de la funci\u00f3n de la prote\u00edna en el mantenimiento de los tel\u00f3meros. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Lidia Chico Dom\u00ednguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Extremadura<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/07\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Germ\u00e1n Larriba Calle<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: tom\u00e1s Gonz\u00e1lez villa <\/li>\n<li>Carlos Guti\u00e9rrez merino (vocal)<\/li>\n<li>Luis Rodriguez dominguez (vocal)<\/li>\n<li>concepci\u00f3n tah\u00eda Ben\u00edtez fern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lidia Chico Dom\u00ednguez El complejo ku participa en procesos de reparaci\u00f3n de da\u00f1os en el dna y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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