{"id":95098,"date":"2009-10-07T00:00:00","date_gmt":"2009-10-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/procyanidin-effects-on-an-impaired-glucose-metabolism-a-further-insight-into-procyanidin-signalling-in-adipose-cells\/"},"modified":"2009-10-07T00:00:00","modified_gmt":"2009-10-07T00:00:00","slug":"procyanidin-effects-on-an-impaired-glucose-metabolism-a-further-insight-into-procyanidin-signalling-in-adipose-cells","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/procyanidin-effects-on-an-impaired-glucose-metabolism-a-further-insight-into-procyanidin-signalling-in-adipose-cells\/","title":{"rendered":"Procyanidin effects on an impaired glucose metabolism: a further insight into procyanidin signalling in adipose cells"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gemma Montagut Pino <\/strong><\/h2>\n<p>A grape-seed derived procyanidins extract (gspe) was reported to mimic some of the physiological effects of insulin. However, gspe showed some divergences when compared to insulin action, which suggests that procyanidins could be useful on a state of impaired insulin action. Therefore, the main purpose of this thesis was to understand how dietary procyanidins modulate glucose metabolism, mainly in adipose tissue and under an insulin resistant condition. results show that a treatment of 25 mg gspe\/kg bw for 30 days on cafeteria-diet-fed rats has a positive effect in improving some insulin resistance parameters and that white adipose tissue is also a clear target for procyanidins. Cell culture studies showed the ability of procyanidins for activating the insulin receptor and its ability for activating proteins kinases involved in the insulin signalling pathway. The gspe study was completed showing that oligomeric structures of gspe can reproduce the total gspe effects.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Procyanidin effects on an impaired glucose metabolism: a further insight into procyanidin signalling in adipose cells<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Procyanidin effects on an impaired glucose metabolism: a further insight into procyanidin signalling in adipose cells <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gemma Montagut Pino <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Rovira i virgili<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/07\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Anna Ard\u00e9vol Grau<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco abraham Tomas barberan <\/li>\n<li>Jos\u00e9 Antonio Fern\u00e1ndez l\u00f3pez (vocal)<\/li>\n<li>francesc Vidal marsal (vocal)<\/li>\n<li>silvia Mora (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gemma Montagut Pino A grape-seed derived procyanidins extract (gspe) was reported to mimic some of the physiological 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