{"id":95264,"date":"2018-03-11T10:15:15","date_gmt":"2018-03-11T10:15:15","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/finding-a-needle-in-a-haystack-the-eukaryotic-selenoproteome\/"},"modified":"2018-03-11T10:15:15","modified_gmt":"2018-03-11T10:15:15","slug":"finding-a-needle-in-a-haystack-the-eukaryotic-selenoproteome","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/finding-a-needle-in-a-haystack-the-eukaryotic-selenoproteome\/","title":{"rendered":"Finding a needle in a haystack: the eukaryotic selenoproteome"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Charles Chapple Artavanis <\/strong><\/h2>\n<p>La selenoproteinas son una diversa familia de proteinas, caracterisada por la presencia  del selenio (se), en la forma del atipico amino acido, selenocisteina (sec). La selenocisteina,  conocida como el amino acido 21, es similar a la cisteina (cys) pero con selenio en vez de azufre (s). A menudo, la proteina omologa de una selenoproteina, se encuentra con cys en la posici\u00f3n de sec en otra especie. Las selenoproteinas son responsables de los effectos biologicos del selenio y se han implicado en la infertilidad masculina, el cancer, enferemedades del corazon, expresion de viruses y envejecimiento.  la selenocisteina se codifica por el codon uga, normalmente un codon stop. Para la  recodificaci\u00f3n correcta del uga son necesarios varios factores. En la 3 prima utr de los transcritos de genes de selenoproteinas eukaryotas, se encuentra una estructura stem- loop, llamada secis. La proteina sbp2 interactua con el secis y el ribosoma y forma un complejo con el factor de elongaci\u00f3n efsec y el trna de la selenocisteina, el trnasec.  dado que el tga normalmente significa el fin de la traduci\u00f3n, las formas tradicionales de busqueda de genes no lo reconocen como codon codificante. Asi, para la predicci\u00f3n de genes de selenoproteinas hace falta desarollar metodolog\u00eda especifica.  en los ultimos a\u00f1os, hemos contribuido a la descripcion del selenoproteoma eukaryota con el discubrimiento de nuevas familias, con la elaboraci\u00f3n de nuevos m\u00e9todos y con la anotaci\u00f3n de differentes selenoproteomas. Finalmente, hemos identificado el primer animal que carece de selenoproteinas, un descubrimiento soprendiente dado que hasta entonces se creia que las selenoproteinas son esenciales por la vida animal.  en resumen, los estudios aqui presentados describen una familia de proteinas particularmente activas en terminos de evoluci\u00f3n y uno de los campos mas interesantes en la biolog\u00eda hoy en d\u00eda.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Finding a needle in a haystack: the eukaryotic selenoproteome<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Finding a needle in a haystack: the eukaryotic selenoproteome <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Charles Chapple Artavanis <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/07\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Roderic Guig\u00f3 Serra<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alain Krol <\/li>\n<li>Mar\u00eda  del mar Alba soler (vocal)<\/li>\n<li>fyodor Kondrashov (vocal)<\/li>\n<li>alfonso Valencia herrera (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Charles Chapple Artavanis La selenoproteinas son una diversa familia de proteinas, caracterisada por la presencia del selenio [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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