{"id":95282,"date":"2018-03-11T10:15:15","date_gmt":"2018-03-11T10:15:15","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-farmacocinetico-farmacodinamico-de-vancomicina-en-pacientes-de-uci\/"},"modified":"2018-03-11T10:15:15","modified_gmt":"2018-03-11T10:15:15","slug":"analisis-farmacocinetico-farmacodinamico-de-vancomicina-en-pacientes-de-uci","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/accion-de-los-farmacos\/analisis-farmacocinetico-farmacodinamico-de-vancomicina-en-pacientes-de-uci\/","title":{"rendered":"An\u00e1lisis farmacocin\u00e9tico-farmacodin\u00e1mico de vancomicina en pacientes de uci"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Natalia Revilla Cuesta <\/strong><\/h2>\n<p>Vancomicina es un antibi\u00f3tico glicop\u00e9ptido de amplia utilizaci\u00f3n en la unidad de cuidados intensivos (uci), dada la elevada frecuencia de aislamiento de staphylococcus aureus meticil\u00edn resistentes en dicho entorno.  los objetivos de la tesis fueron la construcci\u00f3n de un modelo farmacocin\u00e9tico poblacional de vancomicina en pacientes ingresados en la uci, y evaluar la probabilidad de eficacia de diferentes dosis del antibi\u00f3tico frente a varios pat\u00f3genos, teniendo en cuenta criterios farmacocin\u00e9ticos- farmacodin\u00e1micos (pk-pd).   en el primer trabajo experimental se utiliz\u00f3 una poblaci\u00f3n constituida por 46 pacientes adultos ingresados en la uci. La caracterizaci\u00f3n poblacional se llev\u00f3 a cabo mediante el m\u00e9todo est\u00e1ndar en dos etapas. En el segundo trabajo se increment\u00f3 el tama\u00f1o de la poblaci\u00f3n a 191 pacientes, se us\u00f3 el m\u00e9todo no lineal de efectos mixtos para el an\u00e1lisis farmacocin\u00e9tico, y se hizo una validaci\u00f3n externa del modelo poblacional obtenido. En ambos estudios la evaluaci\u00f3n de criterios de dosificaci\u00f3n se realiz\u00f3 mediante simulaci\u00f3n de monte carlo, estim\u00e1ndose la probabilidad de obtener un valor del cociente entre \u00e1rea bajo la curva de concentraci\u00f3n- tiempo de 24 horas y la concentraci\u00f3n m\u00ednima inhibitoria (abc24h\/cmi) \u00c2\u00bf 400 h, para diferentes dosis diarias del antibi\u00f3tico y varios pat\u00f3genos.   los resultados se han plasmado en dos publicaciones, recogidas en la parte experimental de la tesis. Ambas se\u00f1alan un volumen de distribuci\u00f3n elevado de vancomicina en pacientes de uci, y la influencia de la edad, funci\u00f3n renal, gravedad del paciente y alb\u00famina s\u00e9rica sobre el aclaramiento. Los resultados obtenidos mediante simulaci\u00f3n de monte carlo han permitido el dise\u00f1o de un nomograma para la dosificaci\u00f3n inicial de vancomicina en pacientes  uci, considerando la probabilidad de alcanzar los valores recomendados del cociente abc\/cmi. Muestran una elevada probabilidad de infradosificaci\u00f3n con dosis convencionales de vancomicina (2000 mg\/d\u00eda), y de fracaso terap\u00e9utico en presencia de cepas de staphylococcus aureus con susceptibilidad reducida a vancomicina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis farmacocin\u00e9tico-farmacodin\u00e1mico de vancomicina en pacientes de uci<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis farmacocin\u00e9tico-farmacodin\u00e1mico de vancomicina en pacientes de uci <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Natalia Revilla Cuesta <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/07\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ana Mar\u00eda Martin Suarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rosario Calvo duo <\/li>\n<li>Mar\u00eda  victoria Calvo hernandez (vocal)<\/li>\n<li>abelardo Garc\u00eda de lorenzo (vocal)<\/li>\n<li>Manuel Alos almi\u00f1ana (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Natalia Revilla Cuesta Vancomicina es un antibi\u00f3tico glicop\u00e9ptido de amplia utilizaci\u00f3n en la unidad de cuidados intensivos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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