{"id":95353,"date":"2018-03-11T10:15:19","date_gmt":"2018-03-11T10:15:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/searching-for-a-functional-relationship-between-the-breast-cancer-susceptibility-gene-brca1-and-the-progesterone-receptor-in-breast-cancer-cells\/"},"modified":"2018-03-11T10:15:19","modified_gmt":"2018-03-11T10:15:19","slug":"searching-for-a-functional-relationship-between-the-breast-cancer-susceptibility-gene-brca1-and-the-progesterone-receptor-in-breast-cancer-cells","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/searching-for-a-functional-relationship-between-the-breast-cancer-susceptibility-gene-brca1-and-the-progesterone-receptor-in-breast-cancer-cells\/","title":{"rendered":"Searching for a functional relationship between the breast cancer susceptibility gene brca1 and the progesterone receptor in breast cancer cells"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Veronica Alejandra Calvo Vidal <\/strong><\/h2>\n<p>Mutaciones germinales en el gen breast cancer susceptibility gene brca1 aumentan altamente el riesgo de padecer c\u00e1ncer de mama y ovario en mujeres. Se han propuesto diferentes hip\u00f3tesis para explicar esta especificidad de tejido. Una de las hip\u00f3tesis m\u00e1s argumentadas es la que propone una relaci\u00f3n entre brca1 y la acci\u00f3n de las hormonas ov\u00e1ricas. En los \u00faltimos a\u00f1os se han publicado numerosos datos se\u00f1alando al papel esencial del receptor de progesterona (pr) en la inducci\u00f3n del desarrollo normal de la mama y en la formaci\u00f3n del c\u00e1ncer de mama. Este estudio pretend\u00eda buscar una relaci\u00f3n funcional entre brca1 y pr en c\u00e9lulas de c\u00e1ncer de mama. A trav\u00e9s de diferentes estrategias, hemos observado que brca1 inhibe la actividad transcripcional de pr. Hemos investigado en m\u00e1s detalle el mecanismo de este efecto. Brca1 y pr interaccionan in vivo de una manera independiente de ligando. Y lo que es m\u00e1s, brca1 altera la degradaci\u00f3n independiente y dependiente de ligando de pr a trav\u00e9s de su ubiquitinizaci\u00f3n y esto podr\u00eda tener un efecto directo en el nivel de reclutamiento de pr en promotores regulados. Brca1 es reclutado a las regiones de respuesta a hormona de genes diana de pr y afecta la presencia de actividad histona desacetilasa y el nivel de histona h2a monoubiquitinada, estableciendo un enlace entre la acci\u00f3n de brca1 y el estado de la cromatina. Estos hallazgos apoyan una conexi\u00f3n entre brca1, el principal supresor de tumor responsable del c\u00e1ncer de mama hereditario, y la actividad transcripcional del receptor de progesterona. Se puede hipotetizar que esta relaci\u00f3n se ve reflejada en el proceso de tumorig\u00e9nesis brca1-dependiente.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Searching for a functional relationship between the breast cancer susceptibility gene brca1 and the progesterone receptor in breast cancer cells<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Searching for a functional relationship between the breast cancer susceptibility gene brca1 and the progesterone receptor in breast cancer cells <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Veronica Alejandra Calvo Vidal <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/07\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Beato Del Rosal<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: javier Ben\u00edtez ortiz <\/li>\n<li>Mar\u00eda  del mar Vivanco ruiz (vocal)<\/li>\n<li>timothy Thomson okatsu (vocal)<\/li>\n<li>jaume Reventos puigjaner (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Veronica Alejandra Calvo Vidal Mutaciones germinales en el gen breast cancer susceptibility gene brca1 aumentan altamente el 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