{"id":95647,"date":"2018-03-11T10:15:41","date_gmt":"2018-03-11T10:15:41","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-aguda-de-la-contractilidad-intestinal-inducida-por-androgenosmecanismos-celulares\/"},"modified":"2018-03-11T10:15:41","modified_gmt":"2018-03-11T10:15:41","slug":"regulacion-aguda-de-la-contractilidad-intestinal-inducida-por-androgenosmecanismos-celulares","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/regulacion-aguda-de-la-contractilidad-intestinal-inducida-por-androgenosmecanismos-celulares\/","title":{"rendered":"Regulacion aguda de la contractilidad intestinal inducida por androgenos:mecanismos celulares"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Del Carmen Gonzalez Montelongo <\/strong><\/h2>\n<p>Las hormonas esteroideas son mol\u00e9culas sorprendentes. Adem\u00e1s de su capacidad para activar procesos transcripcionales extremadamente espec\u00edficos (a los que llamamos cl\u00e1sicos porque implican la activaci\u00f3n g\u00e9nica dependiente del receptor can\u00f3nico), son capaces de inducir efectos incompatibles con fen\u00f3menos transcripcionales y traduccionales. Fueron r. Pietras y c. Szego los primeros quienes, en la mitad de los a\u00f1os 70 y con no poca dificultad, demostraron la existencia de  efectos agudos tan r\u00e1pidos que eran incompatibles con todas las acciones conocidas para los estr\u00f3genos. Desde entonces han sido muchos los laboratorios que han demostrado acciones fisiol\u00f3gicas de las mol\u00e9culas esteroideas independientes de la activaci\u00f3n de la expresi\u00f3n g\u00e9nica, no s\u00f3lo en tejidos reproductores, sino tambi\u00e9n en tejidos considerados como no dianas.  Hace algunos a\u00f1os, nuestro grupo investigador demostr\u00f3 que los estr\u00f3genos provocaban la relajaci\u00f3n del m\u00fasculo liso intestinal en el curso de segundos. El efecto relajante era espec\u00edfico para estr\u00f3genos y antiestr\u00f3genos y no pod\u00eda ser reproducido por otras hormonas esteroideas. Sin embargo, mientras todos los controles negativos con otras hormonas esteroideas eran inocuos, los andr\u00f3genos cambiaban, de forma sutil, la manera en la que se recuperaban los tejidos de la incubaci\u00f3n hormonal. Los andr\u00f3genos transformaban, sospechosamente, un m\u00fasculo que deber\u00eda entrar en fatiga, en una felicidad contr\u00e1ctil inexplicable. Y este es el punto en que se inicia este trabajo de tesis doctoral. Los andr\u00f3genos han resultado ser poderosos inductores de la potenciaci\u00f3n mec\u00e1nica de la musculatura lisa intestinal ileal y col\u00f3nica. En estos a\u00f1os de duro trabajo, hemos podido caracterizar en detalle estos efectos agudos de los andr\u00f3genos, y los mecanismos celulares y moleculares que subyacen a estos efectos potenciadores han sido desenmascarados&#8230;<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulacion aguda de la contractilidad intestinal inducida por androgenos:mecanismos celulares<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulacion aguda de la contractilidad intestinal inducida por androgenos:mecanismos celulares <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Del Carmen Gonzalez Montelongo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/07\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mario Diaz Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Lorenzo hernandez <\/li>\n<li>leandro Francisco Fern\u00e1ndez p\u00e9rez (vocal)<\/li>\n<li>bego\u00f1a Cantabrana plaza (vocal)<\/li>\n<li>Carlos borja Guerra hern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Del Carmen Gonzalez Montelongo Las hormonas esteroideas son mol\u00e9culas sorprendentes. Adem\u00e1s de su capacidad para activar [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,35,2135,5531,9915],"tags":[9925,9144,154257,125528,196674,16767],"class_list":["post-95647","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-ciencias-de-la-vida","category-fisiologia-endocrina","category-fisiologia-gastrointestinal","category-la-laguna","tag-antonio-lorenzo-hernandez","tag-begona-cantabrana-plaza","tag-carlos-borja-guerra-hernandez","tag-leandro-francisco-fernandez-perez","tag-maria-del-carmen-gonzalez-montelongo","tag-mario-diaz-gonzalez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/95647","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=95647"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/95647\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=95647"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=95647"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=95647"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}