{"id":95666,"date":"2018-03-11T10:15:41","date_gmt":"2018-03-11T10:15:41","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-funcion-supresora-de-tumores-de-p130rbl2-y-p107rbl1-evidencias-geneticas-y-mecanismos-de-accion\/"},"modified":"2018-03-11T10:15:41","modified_gmt":"2018-03-11T10:15:41","slug":"estudio-de-la-funcion-supresora-de-tumores-de-p130rbl2-y-p107rbl1-evidencias-geneticas-y-mecanismos-de-accion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudio-de-la-funcion-supresora-de-tumores-de-p130rbl2-y-p107rbl1-evidencias-geneticas-y-mecanismos-de-accion\/","title":{"rendered":"Estudio de la funci\u00f3n supresora de tumores de p130rbl2 y p107rbl1: evidencias gen\u00e9ticas y mecanismos de acci\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gloria Mart\u00ednez R\u00edo <\/strong><\/h2>\n<p>La familia de prote\u00ednas de retinoblastoma incluye, adem\u00e1s del producto del gene de susceptibilidad a retinoblastoma (prb), otros 2 miembros, p130rbl2 y p107rbl1. Estas 3 prote\u00ednas act\u00faan como inhibidores de la progresi\u00f3n del ciclo celular mediante su uni\u00f3n a los miembtros de la familia de factores de transcripci\u00f3n e2f, a los que inactivan. La capacidad supresora de tumores de prb est\u00e1 ampliamente documentada, tanto en humanos como en modelos animales; en cambio, aunque existen ciertas evidencias que indican que p130 y p107 pueden jugar un papel en el desarrollo de tumores humanos, el estudio de la funci\u00f3n antioncog\u00e9nica de p130 y p107 en animales se ha visto dificultado por la falta de modelos. Los ratones knock-out (ko) para cada uno de los genes, p130 y p107, no desarrollan tumores espont\u00e1neos en un fondo gen\u00e9tico mixto c57bl\/129j. En cambio, se ha descrito que la ausencia de p27kip1, un inhibidor de cdks, en ratones provoca la aparici\u00f3n de tumores espont\u00e1neos de hip\u00f3fisis y de m\u00e9dula adrenal. La inactivaci\u00f3n de p27 colabora con muchos est\u00edmulos protumorales agravando el fenotipo tumoral. Por lo tanto, decidimos obtener ratones ko para p130 y p107 en combinaci\u00f3n con p27, para desenmascarar el posible papel antitumoral de estas prote\u00ednas. El objetivo del presente trabajo es utilizar cepas de ratones que combinen la inactivaci\u00f3n en p130 y p107 con p27 como modelos gen\u00e9ticos para determinar c\u00f3mo contribuyen p130 y p107 al desarrollo tumoral, qu\u00e9 funciones bioqu\u00edmicas de estas mol\u00e9culas son importantes para la tumorig\u00e9nesis y qu\u00e9 genes aparecen alterados debido a la inactivaci\u00f3n de estas prote\u00ednas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la funci\u00f3n supresora de tumores de p130rbl2 y p107rbl1: evidencias gen\u00e9ticas y mecanismos de acci\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la funci\u00f3n supresora de tumores de p130rbl2 y p107rbl1: evidencias gen\u00e9ticas y mecanismos de acci\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gloria Mart\u00ednez R\u00edo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/07\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antxo Vidal Figueroa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Dominguez puente <\/li>\n<li>joan Seoane suarez (vocal)<\/li>\n<li>Manuel Collado rodr\u00edguez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gloria Mart\u00ednez R\u00edo La familia de prote\u00ednas de retinoblastoma incluye, adem\u00e1s del producto del gene de susceptibilidad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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