{"id":95667,"date":"2018-03-11T10:15:41","date_gmt":"2018-03-11T10:15:41","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-regulacion-epigenetica-en-el-sa%c2%adndrome-de-rett\/"},"modified":"2018-03-11T10:15:41","modified_gmt":"2018-03-11T10:15:41","slug":"mecanismos-de-regulacion-epigenetica-en-el-sa%c2%adndrome-de-rett","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-molecular\/mecanismos-de-regulacion-epigenetica-en-el-sa%c2%adndrome-de-rett\/","title":{"rendered":"Mecanismos de regulaci\u00f3n epigen\u00e9tica en el s\u00edndrome de rett"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rocio Gonzalez Urdinguio <\/strong><\/h2>\n<p>El s\u00edndrome de rett (rtt) es una enfermedad neurol\u00f3gica compleja y severa. Esta patolog\u00eda ligada al cromosoma x constituye la segunda causa de retraso mental en mujeres. Un gran hito en el estudio de esta enfermedad fue el descubrimiento de la relaci\u00f3n entre rtt y la presencia de mutaciones en el gen que codifica para la prote\u00edna mecp2 (methyl-cpg binding protein 2). La metilaci\u00f3n del dna en las citosinas incluidas en dinucle\u00f3tidos cpg resulta un mecanismo epigen\u00e9tico importante para la regulaci\u00f3n de la expresi\u00f3n tanto de genes codificantes para prote\u00ednas como de rnas no codificantes, como por ejemplo los micrornas (mirnas). Las prote\u00ednas con afinidad por las metil-cpgs, tales como mecp2, proporcionan un nexo entre la metilaci\u00f3n del dna y la remodelaci\u00f3n de la cromatina. Actualmente, se ha propuesto que mecp2 act\u00faa como un factor transcripcional que relaciona la metilaci\u00f3n del dna y la regulaci\u00f3n de la transcripci\u00f3n.  a pesar de la existencia de varios genes diana de mecp2 identificados, resulta dif\u00edcil explicar c\u00f3mo la disfunci\u00f3n de mecp2 se corresponde finalmente con un s\u00edndrome neurol\u00f3gico. Nuestro trabajo ha analizado diferentes caracter\u00edsticas de la regulaci\u00f3n ejercida por mecp2 en tejido nervioso. Utilizando un modelo murino de rtt, hemos estudiado los patrones globales de las modificaciones de las histonas en cerebro. En este mismo tejido, hemos identificado nuevos genes diana de mecp2 as\u00ed como caracterizado la desregulaci\u00f3n de mirnas en ausencia de mecp2. Tambi\u00e9n hemos analizado los patrones de metilaci\u00f3n del dna en las regiones unidas por mecp2. De este modo, hemos aportado nuevas v\u00edas de estudio para comprender los procesos celulares en los que esta prote\u00edna puede estar involucrada y, as\u00ed, profundizar en el conocimiento de los mecanismos que causan rtt.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos de regulaci\u00f3n epigen\u00e9tica en el s\u00edndrome de rett<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos de regulaci\u00f3n epigen\u00e9tica en el s\u00edndrome de rett <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rocio Gonzalez Urdinguio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/07\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manel Esteller Badosa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  cruz Cigudosa garcia <\/li>\n<li>Marta Izquierdo rojo (vocal)<\/li>\n<li>bego\u00f1a Col\u00e1s escudero (vocal)<\/li>\n<li>esteban Ballestar tarin (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rocio Gonzalez Urdinguio El s\u00edndrome de rett (rtt) es una enfermedad neurol\u00f3gica compleja y severa. Esta patolog\u00eda [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483],"tags":[43574,75741,49759,60398,30251,196704],"class_list":["post-95667","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","tag-begona-colas-escudero","tag-esteban-ballestar-tarin","tag-juan-cruz-cigudosa-garcia","tag-manel-esteller-badosa","tag-marta-izquierdo-rojo","tag-rocio-gonzalez-urdinguio"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/95667","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=95667"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/95667\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=95667"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=95667"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=95667"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}