{"id":95693,"date":"2018-03-11T10:15:45","date_gmt":"2018-03-11T10:15:45","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-bioinformatico-para-la-caracterizacion-de-perfiles-moleculares-asociados-a-metastasis-de-carcinoma-de-prostata-e-identificacion-de-biomarcadores-mediante-tecnicas-anala%c2%adticas\/"},"modified":"2018-03-11T10:15:45","modified_gmt":"2018-03-11T10:15:45","slug":"analisis-bioinformatico-para-la-caracterizacion-de-perfiles-moleculares-asociados-a-metastasis-de-carcinoma-de-prostata-e-identificacion-de-biomarcadores-mediante-tecnicas-anala%c2%adticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/polipeptidos-y-proteinas\/analisis-bioinformatico-para-la-caracterizacion-de-perfiles-moleculares-asociados-a-metastasis-de-carcinoma-de-prostata-e-identificacion-de-biomarcadores-mediante-tecnicas-anala%c2%adticas\/","title":{"rendered":"An\u00e1lisis bioinform\u00e1tico para la caracterizaci\u00f3n de perfiles moleculares asociados a met\u00e1stasis de carcinoma de pr\u00f3stata e identificaci\u00f3n de biomarcadores mediante t\u00e9cnicas anal\u00edticas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alberto Molares Vila <\/strong><\/h2>\n<p>El c\u00e1ncer de pr\u00f3stata es la tercera causa de muerte en varones. El carcinoma de pr\u00f3stata metast\u00e1tico origina consecuencias fatales para la supervivencia de la poblaci\u00f3n. Todav\u00eda se desconocen los mecanismos desencadenantes de la met\u00e1stasis y los estudios encaminados al conocimiento de los biomarcadores de enfermedad metast\u00e1tica son muy limitados. El objetivo de este trabajo es desarrollar y aplicar estrategias  bioinform\u00e1ticas para la selecci\u00f3n de perfiles de biomarcadores que ayuden en la detecci\u00f3n temprana del c\u00e1ncer de pr\u00f3stata metast\u00e1tico. Se emplearon bases de datos de \u00abmicroarrays\u00bb p\u00fablicas para la selecci\u00f3n de un perfil de genes relacionados con la enfermedad metast\u00e1tica. Se encontraron 63 genes diferencialmente expresados y estad\u00edsticamente significativos al usar el test estad\u00edstico u de mann-whitney con correcci\u00f3n de bonferroni. Tambi\u00e9n se emplearon algoritmos de an\u00e1lisis de componentes principales, agrupamientos jer\u00e1rquicos, razonamiento basados en casos y de enriquecimiento de grupos de genes. Se realiz\u00f3 el an\u00e1lisis prote\u00f3mico en dos l\u00edneas celulares de c\u00e1ncer de pr\u00f3stata, una andr\u00f3geno-dependiente (lncap) y otra andr\u00f3geno-resistente (pc3), para identificar los biomarcadores previamente seleccionados. Se desarrollaron t\u00e9cnicas de inmunoprecipitaci\u00f3n basadas en el uso de part\u00edculas magn\u00e9ticas y se aplicaron en el pre-tratamiento de las muestras celulares usando anticuerpos seleccionados. Se emple\u00f3 el western blot en la identificaci\u00f3n proteica. Se realizaron an\u00e1lisis por cromatograf\u00eda l\u00edquida en fase reversa acoplada a espectrometr\u00eda de masas en t\u00e1ndem de ionizaci\u00f3n por electrospray (lc-ms\/ms) con el prop\u00f3sito de caracterizaci\u00f3n de las prote\u00ednas objeto de estudio.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis bioinform\u00e1tico para la caracterizaci\u00f3n de perfiles moleculares asociados a met\u00e1stasis de carcinoma de pr\u00f3stata e identificaci\u00f3n de biomarcadores mediante t\u00e9cnicas anal\u00edticas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis bioinform\u00e1tico para la caracterizaci\u00f3n de perfiles moleculares asociados a met\u00e1stasis de carcinoma de pr\u00f3stata e identificaci\u00f3n de biomarcadores mediante t\u00e9cnicas anal\u00edticas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alberto Molares Vila <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Vigo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/07\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Enrique Caso Pel\u00e1ez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Rodr\u00edguez v\u00e1zquez <\/li>\n<li>Antonio Ojea calvo (vocal)<\/li>\n<li>olga Miroshnychenko (vocal)<\/li>\n<li>gonzalo G\u00f3mez l\u00f3pez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alberto Molares Vila El c\u00e1ncer de pr\u00f3stata es la tercera causa de muerte en varones. El carcinoma [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[679,396,3178,18657],"tags":[196751,20641,129673,166694,18595,196752],"class_list":["post-95693","post","type-post","status-publish","format-standard","hentry","category-analisis-bioquimico","category-polipeptidos-y-proteinas","category-proteinas","category-vigo","tag-alberto-molares-vila","tag-antonio-ojea-calvo","tag-enrique-caso-pelaez","tag-gonzalo-gomez-lopez","tag-jose-antonio-rodriguez-vazquez","tag-olga-miroshnychenko"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/95693","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=95693"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/95693\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=95693"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=95693"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=95693"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}