{"id":95718,"date":"2018-03-11T10:15:45","date_gmt":"2018-03-11T10:15:45","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/proliferacion-linfocitaria-frente-a-peptidos-de-la-mielina-y-su-inhibicion-por-celulas-dendra%c2%adticas-tolerogenicas-en-pacientes-con-esclerosis-multiple\/"},"modified":"2018-03-11T10:15:45","modified_gmt":"2018-03-11T10:15:45","slug":"proliferacion-linfocitaria-frente-a-peptidos-de-la-mielina-y-su-inhibicion-por-celulas-dendra%c2%adticas-tolerogenicas-en-pacientes-con-esclerosis-multiple","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/proliferacion-linfocitaria-frente-a-peptidos-de-la-mielina-y-su-inhibicion-por-celulas-dendra%c2%adticas-tolerogenicas-en-pacientes-con-esclerosis-multiple\/","title":{"rendered":"Proliferaci\u00f3n linfocitaria frente a p\u00e9ptidos de la mielina y su inhibici\u00f3n por c\u00e9lulas dendr\u00edticas tolerog\u00e9nicas en pacientes con esclerosis m\u00faltiple"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Laia Grau Lopez <\/strong><\/h2>\n<p>La esclerosis m\u00faltiple es una enfermedad desmielinizante y cr\u00f3nica del sistema nervioso central de probable etiolog\u00eda autoinmune. Los tratamientos disponibles, no exentos de efectos secundarios, reducen la frecuencia de brotes y contribuyen a una modesta disminuci\u00f3n de la discapacidad, pero no evitan de forma definitiva la progresi\u00f3n de la enfermedad. Por tanto, es necesario el desarrollo de nuevas terapias alternativas al tratamiento farmacol\u00f3gico actual. Una de estas estrategias es la inducci\u00f3n de tolerancia ant\u00edgeno-espec\u00edfica.  en el presente trabajo se exponen los resultados que constituyen una de las bases principales de un posterior ensayo cl\u00ednico de inducci\u00f3n de tolerancia ant\u00edgeno-espec\u00edfica en pacientes con esclerosis m\u00faltiple remitente recurrente mediante el uso de c\u00e9lulas dendr\u00edticas tolerog\u00e9nicas cargadas con p\u00e9ptidos de la mielina. En primer lugar, se demuestra la posibilidad de detectar, en sangre perif\u00e9rica de pacientes con esclerosis m\u00faltiple remitente recurrente, linfocitos t que reaccionan frente a una mezcla seleccionada de p\u00e9ptidos de la mielina. En segundo lugar, se demuestra la posibilidad de obtener c\u00e9lulas dendr\u00edticas tolerog\u00e9nicas derivadas de monocitos de sangre perif\u00e9rica y cargadas con p\u00e9ptidos de la mielina que se muestran fenot\u00edpica y funcionalmente como c\u00e9lulas capaces de inducir tolerancia ant\u00edgeno-espec\u00edfica ya que expresan poca cantidad de mol\u00e9culas coestimuladoras e inducen escasa proliferaci\u00f3n de linfocitos t espec\u00edficos de p\u00e9ptidos de la mielina.  la combinaci\u00f3n de ambos resultados y el conocimiento derivado de trabajos publicados por otros grupos, han permitido el dise\u00f1o de un ensayo cl\u00ednico piloto que tiene como objetivo inducir tolerancia ant\u00edgeno-espec\u00edfica mediante la administraci\u00f3n de c\u00e9lulas dendr\u00edticas tolerog\u00e9nicas en pacientes con esclerosis m\u00faltiple remitente recurrente.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Proliferaci\u00f3n linfocitaria frente a p\u00e9ptidos de la mielina y su inhibici\u00f3n por c\u00e9lulas dendr\u00edticas tolerog\u00e9nicas en pacientes con esclerosis m\u00faltiple<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Proliferaci\u00f3n linfocitaria frente a p\u00e9ptidos de la mielina y su inhibici\u00f3n por c\u00e9lulas dendr\u00edticas tolerog\u00e9nicas en pacientes con esclerosis m\u00faltiple <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Laia Grau Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/07\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eva Mart\u00ednez C\u00e1ceres<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: xavier Montalban gairin <\/li>\n<li>joan Verdaguer autonell (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Laia Grau Lopez La esclerosis m\u00faltiple es una enfermedad desmielinizante y cr\u00f3nica del sistema nervioso central de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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