{"id":95724,"date":"2018-03-11T10:15:45","date_gmt":"2018-03-11T10:15:45","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sintesis-y-estudio-de-nuevos-compuestos-antitumorales-cumarinas-y-antraciclinas\/"},"modified":"2018-03-11T10:15:45","modified_gmt":"2018-03-11T10:15:45","slug":"sintesis-y-estudio-de-nuevos-compuestos-antitumorales-cumarinas-y-antraciclinas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica-farmaceutica\/sintesis-y-estudio-de-nuevos-compuestos-antitumorales-cumarinas-y-antraciclinas\/","title":{"rendered":"Sintesis y estudio de nuevos compuestos antitumorales: cumarinas y antraciclinas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Joana Lobo Antunes <\/strong><\/h2>\n<p>Actualmente el c\u00e1ncer es la segunda causa de muerte en todo el mundo y su incidencia aumenta tanto en t\u00e9rminos absolutos como relativos. Un gran n\u00famero de f\u00e1rmacos usados para su tratamiento presentan un mecanismo de acci\u00f3n conectado con su capacidad de interacci\u00f3n con los \u00e1cidos nucleicos, y en particular, inhibiendo la replicaci\u00f3n del adn.  en la primera parte de la tesis se describe la preparaci\u00f3n de una serie de cumarinas tetrac\u00edclicas con inclusi\u00f3n de \u00e1tomos de hidr\u00f3geno y cadenas laterales de distinta naturaleza, en el intento de obtener compuestos que mantengan la capacidad fotoquimioter\u00e1pica de otros an\u00e1logos no nitrogenados, pero que que pudiesen formar aductos mas estables, y presentar por lo tanto capacidad antitumoral, tambi\u00e9n en ausencia de radiaci\u00f3n  altravioleta-a. De estos compuestos se realiza una evaluaci\u00f3n de su perfil antic\u00e1ncer, as\u00ed como un exahustivo estudio fisicoqu\u00edmico y de interacci\u00f3n biol\u00f3gica.  en la segunda parte de la tesis se estudian con detalle los mecanismos de interacci\u00f3n con macromol\u00e9culas de diferentes antraciclinas derivadas de doxorubicina, y se hace una comparaci\u00f3n entre ellas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis y estudio de nuevos compuestos antitumorales: cumarinas y antraciclinas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis y estudio de nuevos compuestos antitumorales: cumarinas y antraciclinas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Joana Lobo Antunes <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/07\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eugenio Uriarte Villares<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manlio Palumbo <\/li>\n<li>enrique Molina p\u00e9rez (vocal)<\/li>\n<li>Francisco Orallo cambeiro (vocal)<\/li>\n<li>fernanda Borges (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Joana Lobo Antunes Actualmente el c\u00e1ncer es la segunda causa de muerte en todo el mundo y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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