{"id":95754,"date":"2009-03-09T00:00:00","date_gmt":"2009-03-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/fetal-programming-of-cardiovascular-dysfunction-in-intrauterine-growth-restriction\/"},"modified":"2009-03-09T00:00:00","modified_gmt":"2009-03-09T00:00:00","slug":"fetal-programming-of-cardiovascular-dysfunction-in-intrauterine-growth-restriction","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ginecologia\/fetal-programming-of-cardiovascular-dysfunction-in-intrauterine-growth-restriction\/","title":{"rendered":"Fetal programming of cardiovascular dysfunction in intrauterine growth restriction"},"content":{"rendered":"<h2>Tesis doctoral de <strong> F\u00e1tima Crispi Brillas <\/strong><\/h2>\n<p>Introducci\u00f3n el retaso de crecimiento intrauterino (cir), con una preValencia del 5-10% de los reci\u00e9n nacidos, se asocial a un aumento de la mortalidad cardiovascular en vida adulta, pero la fisiopatolog\u00eda de esta correlaci\u00f3n aun es incierta. La principal hip\u00f3tesis de esta tesis fue que el cir induce una disfunci\u00f3n y remodelado cardiovascular primario in \u00fatero que despu\u00e9s persiste en vida postnatal y condiciona un aumento del riesgo cardiovascular en vida adulta.  m\u00e9todos en una cohorte de fetos cir se evalu\u00f3 la funci\u00f3n cardiovascular y se correlacion\u00f3 con el grado de severidad del cir, la presencia de preeclampsia y tambi\u00e9n los resultados perinatales, para poder evaluar su potencial utilidad en el manejo cl\u00ednico de estos fetos. Finalmente, la funci\u00f3n cardiovascular tambi\u00e9n fue evaluada postnatalmente.  resultados en \u00fatero, los fetos cir mostraron signos de disfunci\u00f3n cardiaca subcl\u00ednica medida mediante eco cardiograf\u00eda (aumento de los ratios e\/a i tiempos isovolum\u00e9tricos, con gasto card\u00edaco normal) des de estadios iniciales de severidad. La funci\u00f3n cardiaca mostr\u00f3 un deterioro progresivo con el aumento de severidad del cir, a la vez que aparecieron signos bioqu\u00edmicos de da\u00f1o mioc\u00e1rdico en estadios finales de deterioro (aumento de los niveles de heart-fatty acid binding proteins en sangre de cord\u00f3n). La preeclampsia per se no mostr\u00f3 asociaci\u00f3n con el grado de disfunci\u00f3n cardiaca. Algunos par\u00e1metros de funci\u00f3n cardiaca fetal, como el ductus venoso y el \u00edndice de rendimiento mioc\u00e1rdico, mostraron una asociaci\u00f3n independiente con la mortalidad perinatal en los casos de cir pret\u00e9rmino. A nivel postnatal, los ni\u00f1os con antecedente de cir mostraron cambios en la morfolog\u00eda cardiaca (m\u00e1s globular), disfunci\u00f3n cardiaca subcl\u00ednica (aumento de la frecuencia cardiaca, y reducci\u00f3n del volumen de eyecci\u00f3n y velocidades mioc\u00e1rdicas) y remodelaci\u00f3n vascular (aumento de la presi\u00f3n arterial y grosor de las car\u00f3tidas).  conclusiones los casos de cir presentan una disfunci\u00f3n cardiovascular in \u00fatero que persiste postnatalmente. Los resultados sugieren que el cir induce cambios cardiacos primarios que podr\u00eda explicar la mayor predisposici\u00f3n a patolog\u00eda cardiovascular en vida adulta.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Fetal programming of cardiovascular dysfunction in intrauterine growth restriction<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Fetal programming of cardiovascular dysfunction in intrauterine growth restriction <\/li>\n<li><strong>Autor:<\/strong>\u00a0 F\u00e1tima Crispi Brillas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/09\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduardo Gratacos Solsona<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: torvid Kiserud <\/li>\n<li>jan Deprest (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de F\u00e1tima Crispi Brillas Introducci\u00f3n el retaso de crecimiento intrauterino (cir), con una preValencia del 5-10% de los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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