{"id":95881,"date":"2009-12-09T00:00:00","date_gmt":"2009-12-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/posible-implicacion-del-receptor-dopaminerigo-d2-y-la-aromatasa-p450-en-el-desarrollo-de-adenomas-espontaneos-hipofisarios\/"},"modified":"2009-12-09T00:00:00","modified_gmt":"2009-12-09T00:00:00","slug":"posible-implicacion-del-receptor-dopaminerigo-d2-y-la-aromatasa-p450-en-el-desarrollo-de-adenomas-espontaneos-hipofisarios","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/patologia-clinica\/posible-implicacion-del-receptor-dopaminerigo-d2-y-la-aromatasa-p450-en-el-desarrollo-de-adenomas-espontaneos-hipofisarios\/","title":{"rendered":"Posible implicaci\u00f3n del receptor dopamin\u00e9rigo d2 y la aromatasa p450 en el desarrollo de adenomas espont\u00e1neos hipofisarios"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sonia Gutierrez Gabriel <\/strong><\/h2>\n<p>Tras el an\u00e1lisis inmunocitoqu\u00edmico de adenomas hipofisarios en ratas viejas, en ratones knock out para aromatasa y receptor dopamin\u00e9rgico d2, y en hip\u00f3fisis humanas, se comparan los resultados obtenidos con los datos existentes en la literatura. La aromatasa p450 parece directamente implicada en la g\u00e9nesis de los prolactinomas murinos y humanos, ya que todos los prolactinomas estudiados, humanos o de rata, fueron positivos al enzima y los ratones knock out para el enzima nunca desarrollaron prolactinomas. la participaci\u00f3n de la inhibici\u00f3n dopamin\u00e9rgica en impedir la g\u00e9nesis de los prolactinomas es evidente, como se deriva de los resultados obtenidos en ratones knock out para el receptor d2, que confiman los hallazgos descritos por otros autores previamente. En los prolactinomas espont\u00e1neos obtenidos en ratas y en humanos, la isoforma d2l del receptor dopamin\u00e9rgico d2 est\u00e1 hiperexpresada y coexiste en las c\u00e9lulas hipofisarias con la localizaci\u00f3n de las c\u00e9lulas de prolactina y de aromatasa, lo que sugiere que la posible aromatizaci\u00f3n de la testosterona a estradiol no impide la expresi\u00f3n del receptor dopamin\u00e9rgico d2l. estos resultados sugieren que la presencia de esta isoforma del receptor podr\u00eda estar implicada en un descenso del control inhibidor dopamin\u00e9rgico del n\u00famero de c\u00e9lulas hipofisarias productoras de prolactina, que podr\u00eda ser desarrollada a trav\u00e9s de la isoforma d2s del mismo receptor. analizados conjuntamente, de nuestros resultados parece deducirse que es m\u00e1s importante la producci\u00f3n local de estradiol dependiente de la actuaci\u00f3n de la aromatasa p450 que un d\u00e9ficit en la inhibici\u00f3n dopamin\u00e9rgica para el desarrollo de los prolactinomas en rata, rat\u00f3n y humanos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Posible implicaci\u00f3n del receptor dopamin\u00e9rigo d2 y la aromatasa p450 en el desarrollo de adenomas espont\u00e1neos hipofisarios<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Posible implicaci\u00f3n del receptor dopamin\u00e9rigo d2 y la aromatasa p450 en el desarrollo de adenomas espont\u00e1neos hipofisarios <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sonia Gutierrez Gabriel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/09\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Carretero Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ricardo Vazquez rodriguez <\/li>\n<li>Mar\u00eda  teresa V\u00e1zquez osorio (vocal)<\/li>\n<li>ferm\u00edn Viejo tirado (vocal)<\/li>\n<li>Jos\u00e9 ramon Sa\u00f1udo tejero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sonia Gutierrez Gabriel Tras el an\u00e1lisis inmunocitoqu\u00edmico de adenomas hipofisarios en ratas viejas, en ratones knock out [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[851,384,1323,9386],"tags":[72746,9521,70752,149706,2012,197080],"class_list":["post-95881","post","type-post","status-publish","format-standard","hentry","category-endocrinologia","category-patologia-clinica","category-patologia-experimental","category-salamanca","tag-fermin-viejo-tirado","tag-jose-carretero-gonzalez","tag-jose-ramon-sanudo-tejero","tag-maria-teresa-vazquez-osorio","tag-ricardo-vazquez-rodriguez","tag-sonia-gutierrez-gabriel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/95881","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=95881"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/95881\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=95881"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=95881"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=95881"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}