{"id":96012,"date":"2018-03-11T10:16:08","date_gmt":"2018-03-11T10:16:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-regulacion-del-enizma-de-conversion-de-la-endotelina-1-ece-1-importancia-en-algunas-situaciones-fisiopatologicas\/"},"modified":"2018-03-11T10:16:08","modified_gmt":"2018-03-11T10:16:08","slug":"mecanismos-de-regulacion-del-enizma-de-conversion-de-la-endotelina-1-ece-1-importancia-en-algunas-situaciones-fisiopatologicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/nefrologia\/mecanismos-de-regulacion-del-enizma-de-conversion-de-la-endotelina-1-ece-1-importancia-en-algunas-situaciones-fisiopatologicas\/","title":{"rendered":"Mecanismos de regulaci\u00f3n del enizma de conversi\u00f3n de la endotelina-1 (ece-1). importancia en algunas situaciones fisiopatol\u00f3gicas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ingrid Viviana Raoch Michaels <\/strong><\/h2>\n<p>El enzima de conversi\u00f3n de la endotelina-1, ece-1 es una prote\u00edna clave en la regulaci\u00f3n de la endotelina por parte de las c\u00e9lulas endoteliales. El objetivo de la tesis es estudiar su regulaci\u00f3n fisiol\u00f3gica o farmacol\u00f3gica y su importancia en el desarrollo de aterosclerosis. Mediante experimentos realizados in vitro e in vivo, utilizando ratones deficientes en apo e, o c\u00e9lulas circulante de sangre perif\u00e9rica extra\u00eddas de pacientes hipercolesterol\u00e9micos, se estudia el efecto sobre su expresi\u00f3n de inhibidores farmacol\u00f3gicos, del \u00f3xido n\u00edtrico y de las ldl oxidadas. Los resultados muestran una compleja regulaci\u00f3n: 1. Los inhibidores de la actividad ece-1, aumentan la expresi\u00f3n de la prote\u00edna, al aumentar los niveles del precursor inactivo, big endotelina 1, 2. Los donadores de \u00f3xido n\u00edtrico, inducen una reducci\u00f3n en la cantidad de la enzima, desestabilizando su arn mensajero. 3. El incremento de ldl oxidadas, observado en la aterosclerosis, produce un incremento en los niveles de ece-1. Este aumento puede ser, en parte responsable de la hipertensi\u00f3n que se produce en ratones o pacientes hipercolesterol\u00e9micos. en conclusi\u00f3n, la compleja regulaci\u00f3n de ece-1 en la que se encuentran implicados metabolitos de la cascada de s\u00edntesis de la propia endotelina y otros autacoides endoteliales, apoya la relevancia fisiol\u00f3gica de la enzima en la modulaci\u00f3n de la funci\u00f3n vascular. Por otro lado, ece-1 puede ejercer un papel patog\u00e9nico en la generaci\u00f3n de alteraciones estructurales y funcionales de la aterosclerosis y puede constituir una diana terap\u00e9utica valiosa en el control de este proceso.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos de regulaci\u00f3n del enizma de conversi\u00f3n de la endotelina-1 (ece-1). importancia en algunas situaciones fisiopatol\u00f3gicas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos de regulaci\u00f3n del enizma de conversi\u00f3n de la endotelina-1 (ece-1). importancia en algunas situaciones fisiopatol\u00f3gicas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ingrid Viviana Raoch Michaels <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/09\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Susana L\u00f3pez Ongil<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: M\u00aa Luisa D\u00edez marqu\u00e9s <\/li>\n<li>alicia Rodr\u00edguez barbero (vocal)<\/li>\n<li>Jos\u00e9 Manuel Valdivieso revilla (vocal)<\/li>\n<li>Fernando Rodr\u00edguez pascual (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ingrid Viviana Raoch Michaels El enzima de conversi\u00f3n de la endotelina-1, ece-1 es una prote\u00edna clave en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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