{"id":96040,"date":"2018-03-11T10:16:08","date_gmt":"2018-03-11T10:16:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-de-la-protea%c2%adna-x-del-virus-de-la-hepatitis-b-en-la-fibrosis-hepaticaactivacion-de-las-celulas-estrelladas-hepaticas\/"},"modified":"2018-03-11T10:16:08","modified_gmt":"2018-03-11T10:16:08","slug":"implicacion-de-la-protea%c2%adna-x-del-virus-de-la-hepatitis-b-en-la-fibrosis-hepaticaactivacion-de-las-celulas-estrelladas-hepaticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-de-la-protea%c2%adna-x-del-virus-de-la-hepatitis-b-en-la-fibrosis-hepaticaactivacion-de-las-celulas-estrelladas-hepaticas\/","title":{"rendered":"Implicaci\u00f3n de la prote\u00edna x del virus de la hepatitis b en la fibrosis hep\u00e1tica:activaci\u00f3n de las c\u00e9lulas estrelladas hep\u00e1ticas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Samuel Martin Vilchez <\/strong><\/h2>\n<p>Null resumen  la hepatitis cr\u00f3nica producida por la infecci\u00f3n del virus de la hepatitis b es la principal causa de fibrosis hep\u00e1tica, la cual puede evolucionar hac\u00eda fases m\u00e1s avanzadas de la enfermedad como son la cirrosis y el hepatocarcinoma. El papel de la prote\u00edna x del virus de la hepatitis b sobre la replicaci\u00f3n viral y el desarrollo de hepatocarcinoma esta extensamente estudiado. Sin embargo el posible efecto que la prote\u00edna x pudiera tener en estadios menos avanzados de la patolog\u00eda hep\u00e1tica  como es la fibrosis no ha sido estudiado con detalle. en este trabajo se pone de manifiesto como la prote\u00edna x ejerce un papel importante sobre la fibrosis hep\u00e1tica, por medio de las c\u00e9lulas estrelladas hep\u00e1ticas. Este tipo celular es clave para el inicio y desarrollo de la fibrosis y es el principal responsable de la s\u00edntesis y acumulaci\u00f3n de elementos de matriz extracelular caracter\u00edstico del proceso fibr\u00f3tico. Los experimentos que hemos realizado muestran como de forma paracrina hbx ejerce s u efecto sobre las c\u00e9lulas estrelladas del h\u00edgado, provocando activaci\u00f3n y proliferaci\u00f3n. En este proceso detectamos el incremento de prote\u00ednas t\u00edpicas de los procesos asociados a la fibrosis como son el remodelado de matriz celular, fibrog\u00e9nesis, re flejado en la s\u00edntesis de col\u00e1geno-i, mmp2, ctgf, tgf-beta. el incremento en la secreci\u00f3n de tgf-beta por parte de hepatocitos capaces de expresar hbx, pone de manifiesto que la acci\u00f3n de la prote\u00edna viral sobre las c\u00e9lulas estrelladas del h\u00edgado es de tipo paracrino y mediada principalmente v\u00eda tgf-beta, esto lo demuestra el hecho de que el incremento de los niveles de prote\u00ednas y factores de crecimiento relacionados con el proceso de fibrosis as\u00ed como los fen\u00f3menos de activaci\u00f3n y proliferaci\u00f3 n de las c\u00e9lulas estrelladas hep\u00e1ticas son neutralizados al bloquear la se\u00f1alizaci\u00f3n a trav\u00e9s de tgf-beta.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaci\u00f3n de la prote\u00edna x del virus de la hepatitis b en la fibrosis hep\u00e1tica:activaci\u00f3n de las c\u00e9lulas estrelladas hep\u00e1ticas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaci\u00f3n de la prote\u00edna x del virus de la hepatitis b en la fibrosis hep\u00e1tica:activaci\u00f3n de las c\u00e9lulas estrelladas hep\u00e1ticas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Samuel Martin Vilchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/09\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ricardo Moreno Otero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rosa Mar\u00eda  (secretario) Arahuetes portero <\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Samuel Martin Vilchez Null resumen la hepatitis cr\u00f3nica producida por la infecci\u00f3n del virus de la hepatitis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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