{"id":96216,"date":"2018-03-11T10:16:21","date_gmt":"2018-03-11T10:16:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-funcional-de-las-protea%c2%adnas-bgs-subunidades-catala%c2%adticas-de-la-b-13-glucan-sintasa-de-schizosaccharomyces-pombe\/"},"modified":"2018-03-11T10:16:21","modified_gmt":"2018-03-11T10:16:21","slug":"analisis-funcional-de-las-protea%c2%adnas-bgs-subunidades-catala%c2%adticas-de-la-b-13-glucan-sintasa-de-schizosaccharomyces-pombe","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/analisis-funcional-de-las-protea%c2%adnas-bgs-subunidades-catala%c2%adticas-de-la-b-13-glucan-sintasa-de-schizosaccharomyces-pombe\/","title":{"rendered":"An\u00e1lisis funcional de las prote\u00ednas bgs, subunidades catal\u00edticas de la b (1,3) gluc\u00e1n sintasa de schizosaccharomyces pombe"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ivone Marisa Pereira  Martins <\/strong><\/h2>\n<p>La pared celular es una estructura adecuada para la b\u00fasqueda de nuevos agentes antif\u00fangicos, ya que es una estructura selectiva y vital para la c\u00e9lula f\u00fangica.  hemos realizado el estudio comparativo de los mecanismos de acci\u00f3n de las tres familias de antif\u00fangicos espec\u00edficos contra la s\u00edntesis de \u00edY(1,3)glucano: papulacandina, enfumafungina, equinocandina y su derivado comercial cancidas. Hemos hecho tambi\u00e9n un estudio comparativo funcional de las prote\u00ednas bgs1p, bgs3p y bgs4p, esenciales para la c\u00e9lula vegetativa. el cancidas ha mostrado ser el mejor antif\u00fangico in vivo de las tres familias analizadas, mostrando una cmi mucho menor que el resto de antif\u00fangicos ensayados. Tambi\u00e9n ha mostrado una notable capacidad inhibitoria in vitro sobre la actividad \u00edY(1,3)gluc\u00e1n sintasa, 100 veces superior a la de otros antif\u00fangicos. No obstante, la papulacandina ha resultado tener una capacidad inhibitoria 100 veces mayor que el cancidas. Su patr\u00f3n de inhibici\u00f3n in vitro de la actividad \u00edY(1,3)gluc\u00e1n sintasa se divide en tres etapas.  todos los procesos de resistencia a antif\u00fangicos espec\u00edficos contra la s\u00edntesis del \u00edY(1,3)glucano est\u00e1n conferidos \u00fanicamente por bgs4p. Las mutaciones fks de resistencia descritas para s. Cerevisiae no confieren en bgs4p un fenotipo de resistencia a papulacandina y enfumafungina pero si a equinocandina y cancidas. Se han definido dominios de hipersensiblidad a los antif\u00fangicos en las tres prote\u00ednas bgs, que no se corresponden con una alteraci\u00f3n de la actividad enzim\u00e1tica \u00edY(1,3)gluc\u00e1n sintasa. los fenotipos del mutante bgs1fks2-1sugieren que bgs1p es responsable, de otros procesos tales como la correcta formaci\u00f3n de un \u00fanico anillo contr\u00e1ctil. la ausencia de marca interna de septo primario en todos los mutantes de bgs3p sugiere que bgs3p podr\u00eda ser responsable de la s\u00edntesis del glucano lineal y del septo primario, actuando despu\u00e9s de que bgs1p haya iniciado la s\u00edntesis de dicha estructura. bgs4p parece ser el responsable de la actividad \u00edY(1,3)gluc\u00e1n sintasa mayoritaria detectada in vitro. Las mutaciones de bgs4p apoyan la idea de que la funci\u00f3n principal de esta prote\u00edna es el mantenimiento de la integridad celular, principalmente durante la septaci\u00f3n. El defecto en degradaci\u00f3n del septo de algunos mutantes de bgs4p sugiere que esta prote\u00edna regular\u00eda la localizaci\u00f3n y\/o la actividad de componentes esenciales en el proceso de separaci\u00f3n celular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis funcional de las prote\u00ednas bgs, subunidades catal\u00edticas de la b (1,3) gluc\u00e1n sintasa de schizosaccharomyces pombe<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis funcional de las prote\u00ednas bgs, subunidades catal\u00edticas de la b (1,3) gluc\u00e1n sintasa de schizosaccharomyces pombe <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ivone Marisa Pereira  Martins <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/09\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>\u00e1ngel Duran Bravo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  del pilar Perez gonzalez <\/li>\n<li>altino Branco choupina (vocal)<\/li>\n<li>Manuel Ramirez fernandez (vocal)<\/li>\n<li>yolanda Sanchez martin (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ivone Marisa Pereira Martins La pared celular es una estructura adecuada para la b\u00fasqueda de nuevos agentes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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