{"id":96227,"date":"2018-03-11T10:16:26","date_gmt":"2018-03-11T10:16:26","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/neoadyuvancia-con-oxaliplatino-en-camcer-de-recto-contribucion-en-respuesta-patologica-y-pronostico\/"},"modified":"2018-03-11T10:16:26","modified_gmt":"2018-03-11T10:16:26","slug":"neoadyuvancia-con-oxaliplatino-en-camcer-de-recto-contribucion-en-respuesta-patologica-y-pronostico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/neoadyuvancia-con-oxaliplatino-en-camcer-de-recto-contribucion-en-respuesta-patologica-y-pronostico\/","title":{"rendered":"Neoadyuvancia con oxaliplatino en c\u00e1mcer de recto: contribuci\u00f3n en respuesta patol\u00f3gica y pron\u00f3stico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Javier Serrano Andreu <\/strong><\/h2>\n<p>El objetivo de esta tesis es analizar la eficacia en t\u00e9rminos de respuesta patol\u00f3gica, preservaci\u00f3n esfinteriana y pron\u00f3stico cl\u00ednico, de un nuevo esquema de quimio-irradiaci\u00f3n preoperatoria en c\u00e1ncer de recto localmente avanzado que incluye oxalipla tino (f\u00e1rmaco muy activo en c\u00e1ncer de recto metast\u00e1sico) al protocolo est\u00e1ndar de quimio-radioterapia preoperatoria. Se ha dise\u00f1ado un estudio comparativo de dos cohortes de pacientes (n=65 y n=92) reclutados prospectivamente y analizados retrospecti vamente, utilizando el protocolo estandar de tratamiento (radio-quimioterapia basada en fluoropirimidinas, resecci\u00f3n quir\u00fargica con radioterapia intraoperatoria y quimioterapia adyuvante) o el nuevo esquema neoadyuvante, que consisti\u00f3 en dos ciclos d e oxaliplatino de inducci\u00f3n (folfox-4), seguidos del esquema preoperatorio convencional. El \u00edndice de cumplimiento terap\u00e9utico del nuevo protocolo neoadyuvante fue cercano al 90 , con una incidencia de eventos t\u00f3xicos severos (grado 3-4) del 33  de l os pacientes. Los resultados identifican que el oxaliplatino como tratamiento de inducci\u00f3n facilita la preservaci\u00f3n esfinteriana en pacientes de alto riesgo de amputaci\u00f3n (40  vs. 8 ), incrementa la tasa de respuestas patol\u00f3gicas completas (24  vs. 9  ) y contribuye a lograr excelentes resultados en t\u00e9rminos de control local tumoral (92 ), supervivencia libre de enfermedad (74  a 5 a\u00f1os) y supervivencia global (81  a 5 a\u00f1os). Estos datos animan a dise\u00f1ar nuevos estudios que confirmen estos buenos  resultados con la inclusi\u00f3n del oxaliplatino en programas de quimio-irradiaci\u00f3n preoperatoria para el tratamiento del c\u00e1ncer de recto localmente avanzado.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Neoadyuvancia con oxaliplatino en c\u00e1mcer de recto: contribuci\u00f3n en respuesta patol\u00f3gica y pron\u00f3stico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Neoadyuvancia con oxaliplatino en c\u00e1mcer de recto: contribuci\u00f3n en respuesta patol\u00f3gica y pron\u00f3stico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Javier Serrano Andreu <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/09\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Felipe Angel Calvo Manuel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Carreras delgado <\/li>\n<li>albert Biete sol\u00ed\u00a0 (vocal)<\/li>\n<li>damian Garc\u00eda olmo (vocal)<\/li>\n<li>Jes\u00fas Garcia foncillas lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Javier Serrano Andreu El objetivo de esta tesis es analizar la eficacia en t\u00e9rminos de respuesta [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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