{"id":96254,"date":"2018-03-11T10:16:26","date_gmt":"2018-03-11T10:16:26","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estructura-y-funcion-de-los-transportadores-de-aminoacidos-adic-como-paradigma-de-los-transportadores-apc\/"},"modified":"2018-03-11T10:16:26","modified_gmt":"2018-03-11T10:16:26","slug":"estructura-y-funcion-de-los-transportadores-de-aminoacidos-adic-como-paradigma-de-los-transportadores-apc","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estructura-y-funcion-de-los-transportadores-de-aminoacidos-adic-como-paradigma-de-los-transportadores-apc\/","title":{"rendered":"Estructura y funci\u00f3n de los transportadores de amino\u00e1cidos: adic como paradigma de los transportadores apc."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Merc\u00e9 Ratera Bastardas <\/strong><\/h2>\n<p>La b\u00fasqueda de hom\u00f3logos procariotas a las subunidades ligeras de los transportadores heterom\u00e9ricos de amino\u00ed\u00a0cidos conllev\u00f3 la selecci\u00f3n de 13 prote\u00ednas candidatas para estudios de estructura-funci\u00f3n de estos citados transportadores. Por estudios de estabilidad de la proteina pura junto a la caracterizaci\u00f3n funcional y estructural de los hom\u00f3logos procariotas seleccionados se encontr\u00f3 el intercambiador de arginina:agmatina, adic, como mejor candidato para los estudis de estructura-funci\u00f3n. Se determin\u00f3 el tript\u00f3fano en la posici\u00f3n 293 de la proteina adic responsable de la uni\u00f3n del sustrato arginina dada la existencia de una interacci\u00f3n cation-\u00c2\u00bf entre el grupo guanidinio del sustrato arginina con los anillos aromaticos del tript\u00f3fano en esta posici\u00f3n. La g292 se consider\u00f3 estar tambi\u00e9n cerca del sitio de uni\u00f3n del sustrato. El cristal bidimensional del mutante puntual de adic_w293l dio la proyecci\u00f3n de la primera estructura a nivel subnanometrico de un transportador de la gran familia de transportadores apc. Por comparaci\u00f3n con las recientes estructuras at\u00ed\u00b2micas del mismo transportador adic y de un segundo miembro cristalizado a alta resoluci\u00f3n de la familia apc (apct)  se ha llegado a la conlcusi\u00f3n que el mutante puntual w293l de adic presenta una confomaci\u00f3n distinta a los transportadores cristalizados en 3d.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estructura y funci\u00f3n de los transportadores de amino\u00e1cidos: adic como paradigma de los transportadores apc.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estructura y funci\u00f3n de los transportadores de amino\u00e1cidos: adic como paradigma de los transportadores apc. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Merc\u00e9 Ratera Bastardas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/09\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Palac\u00edn Prieto<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: mar\u00ed\u00a7al Pastor anglada <\/li>\n<li>Francisco Javier Casado merediz (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Merc\u00e9 Ratera Bastardas La b\u00fasqueda de hom\u00f3logos procariotas a las subunidades ligeras de los transportadores heterom\u00e9ricos de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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