{"id":96285,"date":"2018-03-11T10:16:30","date_gmt":"2018-03-11T10:16:30","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/the-role-of-the-spn42dd-serpin-in-the-innate-immune-response-in-drosophila-melanogaster\/"},"modified":"2018-03-11T10:16:30","modified_gmt":"2018-03-11T10:16:30","slug":"the-role-of-the-spn42dd-serpin-in-the-innate-immune-response-in-drosophila-melanogaster","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/inmunologia\/the-role-of-the-spn42dd-serpin-in-the-innate-immune-response-in-drosophila-melanogaster\/","title":{"rendered":"The role of the spn42dd serpin in the innate immune response in drosophila melanogaster"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ane Fullaondo Zabala <\/strong><\/h2>\n<p>The drosophila genome encodes 29 serpin genes, the biological functions of most  which are unknown. In this report, the biochemical and functional characterisation of  serpin42dd (spn42dd, synonyms: spn1, cg9456) is presented. Spn42dd inhibits  trypsin in vitro and regulates the toll-mediated immune response in vivo. Both the  transcription and protein levels of spn42dd are up-regulated in flies infected by grampositive  bacteria and fungi. Moreover, transgenic flies over-expressing spn42dd show  reduced expression of drosomycin antimicrobial peptide after fungal, but not bacterial  challenge.  the toll-mediated anti-fungal immune response can be activated either by the  pattern recognition receptor, gnbp3, or the virulence-factor (danger-signalling)  response. The danger-signalling pathway senses both fungal and gram-positive bacterial  virulence factors and involves the serine protease persephone. Spn42dd does not affect  this persephone-dependent branch of the toll-signalling pathway, which is independently  modulated by the necrotic serpin (spn43ac, cg1857). In fact, epistatic analysis places  the spn42dd inhibitor downstream of the gnbp3 receptor and upstream of the grass  protease.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>The role of the spn42dd serpin in the innate immune response in drosophila melanogaster<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 The role of the spn42dd serpin in the innate immune response in drosophila melanogaster <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ane Fullaondo Zabala <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/09\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>David Gubb<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: dominique Ferrandon <\/li>\n<li>james Sutherland (vocal)<\/li>\n<li>tim Dafforn (vocal)<\/li>\n<li>isabel Guerrero vega (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ane Fullaondo Zabala The drosophila genome encodes 29 serpin genes, the biological functions of most which are [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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