{"id":96355,"date":"2009-02-10T00:00:00","date_gmt":"2009-02-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-una-acetiltransferasa-implicada-en-la-biosa%c2%adntesis-del-antitumoral-cromomicina-a3-y-su-utilizacion-para-la-generacion-de-nuevos-derivados\/"},"modified":"2009-02-10T00:00:00","modified_gmt":"2009-02-10T00:00:00","slug":"caracterizacion-de-una-acetiltransferasa-implicada-en-la-biosa%c2%adntesis-del-antitumoral-cromomicina-a3-y-su-utilizacion-para-la-generacion-de-nuevos-derivados","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/metabolismo-microbiano\/caracterizacion-de-una-acetiltransferasa-implicada-en-la-biosa%c2%adntesis-del-antitumoral-cromomicina-a3-y-su-utilizacion-para-la-generacion-de-nuevos-derivados\/","title":{"rendered":"Caracterizaci\u00f3n de una acetiltransferasa implicada en la bios\u00edntesis del antitumoral cromomicina a3 y su utilizaci\u00f3n para la generaci\u00f3n de  nuevos derivados"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Beatriz Garc\u00eda Fern\u00e1ndez <\/strong><\/h2>\n<p>Los miembros del g\u00e9nero streptomyces, sintetizan un gran n\u00famero de mol\u00e9culas bioactivas entre los cuales se encuentran el antitumoral cromomicina a3.  Dada la importancia de la acetilaci\u00f3n de los az\u00facares para la bioactividad de la mol\u00e9cula de cromomicina a3, se estudi\u00f3 la acetiltransferasa cmma responsable de catalizar las dos transferencias de grupos acetilo a los az\u00facares de la mol\u00e9cula.  La flexibilidad de sustrato de la acetiltransferasa fue utilizada con el fin de generar nuevos compuestos que podr\u00edan ver incrementada su actividad, puesto que es capaz de transferir diversos grupos acilos a distintas mol\u00e9culas, generando as\u00ed nuevos derivados acetilados de antitumorales como el caso de la mitramicina cuya actividad se vi\u00f3 modificada por el grupo acetilo a\u00f1adido por la acetiltransferasa cmma.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de una acetiltransferasa implicada en la bios\u00edntesis del antitumoral cromomicina a3 y su utilizaci\u00f3n para la generaci\u00f3n de  nuevos derivados<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de una acetiltransferasa implicada en la bios\u00edntesis del antitumoral cromomicina a3 y su utilizaci\u00f3n para la generaci\u00f3n de  nuevos derivados <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Beatriz Garc\u00eda Fern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/10\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M\u00aa Del Carmen M\u00e9ndez Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Parra fernandez <\/li>\n<li>Mar\u00eda enriqueta Arias fern\u00e1ndez (vocal)<\/li>\n<li>Francisco Malpartida romero (vocal)<\/li>\n<li>Francisco Mor\u00eds varas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Beatriz Garc\u00eda Fern\u00e1ndez Los miembros del g\u00e9nero streptomyces, sintetizan un gran n\u00famero de mol\u00e9culas bioactivas entre los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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