{"id":96430,"date":"2009-06-10T00:00:00","date_gmt":"2009-06-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-compuestos-inhibidores-de-stat6-aplicacion-terapeutica-en-modelo-murino-de-asma-bronquial\/"},"modified":"2009-06-10T00:00:00","modified_gmt":"2009-06-10T00:00:00","slug":"desarrollo-de-compuestos-inhibidores-de-stat6-aplicacion-terapeutica-en-modelo-murino-de-asma-bronquial","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/inmunopatologia\/desarrollo-de-compuestos-inhibidores-de-stat6-aplicacion-terapeutica-en-modelo-murino-de-asma-bronquial\/","title":{"rendered":"Desarrollo de compuestos inhibidores de stat6: aplicaci\u00f3n terap\u00e9utica en modelo murino de asma bronquial"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Rodr\u00edguez Cort\u00e9s <\/strong><\/h2>\n<p>El asma bronquial es una enfermedad inflamatoria que representa un gran problema sociosanitario debido a su alta incidencia, agravada por el aumento de la preValencia que est\u00e1 experimentando. Por lo tanto, existe un gran inter\u00e9s en desarrollar nuevas terapias m\u00e1s eficaces. Estudios realizados en humanos y en modelos animales indican que la il-4 e il-13 tienen un papel central en asma mediado a trav\u00e9s del factor de transcripci\u00f3n stat6. Esto sugiere que stat6 puede servir de diana para futuros tratamientos. Por tanto, compuestos capaces de inhibir la activaci\u00f3n de stat6 podr\u00edan ser muy \u00fatiles en asma. El objetivo de este trabajo es el dise\u00f1o y el desarrollo de nuevos compuestos, utilizando como compuesto l\u00edder el \u00e1cido salic\u00edlico, capaces de inhibir la activaci\u00f3n de stat6 por la il-4 y la il-13 y valorar su eficacia en un modelo murino de asma bronquial.  este trabajo ha permitido descubrir compuestos que inhiben la activaci\u00f3n de stat6 por la il-4 e il-13, uno de los cuales result\u00f3 eficaz en el tratamiento del asma en un modelo murino experimental, inhibiendo los procesos inflamatorios implicados en esta enfermedad. Este compuesto puede servir de base para desarrollar nuevas terapias frente al asma.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo de compuestos inhibidores de stat6: aplicaci\u00f3n terap\u00e9utica en modelo murino de asma bronquial<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo de compuestos inhibidores de stat6: aplicaci\u00f3n terap\u00e9utica en modelo murino de asma bronquial <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Rodr\u00edguez Cort\u00e9s <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Extremadura<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/10\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Fern\u00e1ndez Marcos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Jes\u00fas Garc\u00eda mar\u00edn <\/li>\n<li>Ana Mar\u00eda Garc\u00eda collazo (vocal)<\/li>\n<li>africa Gonzalez fernandez (vocal)<\/li>\n<li>Juan  Francisco Sanchez mu\u00f1oz-torrero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Rodr\u00edguez Cort\u00e9s El asma bronquial es una enfermedad inflamatoria que representa un gran problema sociosanitario debido [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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