{"id":96440,"date":"2009-06-10T00:00:00","date_gmt":"2009-06-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/relacion-epigenetica-de-la-via-wnt-en-la-leucemia-aguda-linfoblastica\/"},"modified":"2009-06-10T00:00:00","modified_gmt":"2009-06-10T00:00:00","slug":"relacion-epigenetica-de-la-via-wnt-en-la-leucemia-aguda-linfoblastica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/medicina-interna\/relacion-epigenetica-de-la-via-wnt-en-la-leucemia-aguda-linfoblastica\/","title":{"rendered":"Relacion epigenetica  de la via wnt en la leucemia aguda linfobl\u00e1stica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Vanesa Martin Palanco <\/strong><\/h2>\n<p>La v\u00eda wnt constituye un regulador cr\u00edtico en los procesos de renovaci\u00f3n celular de las c\u00e9lulas madre y de las c\u00e9lulas tumorales permitiendo as\u00ed la proliferaci\u00f3n de las mismas y la g\u00e9nesis tumoral. A trav\u00e9s de la v\u00eda can\u00f3nica, cuyo mediador central es \u00edY-catenina, la v\u00eda wnt induce la expresi\u00f3n de genes diana como ciclina d1 y c-myc. Esta v\u00eda de activaci\u00f3n esta controlada por un n\u00famero de antagonistas  como dkk3, sfrp1, sfrp2, sfrp4, sfrp5, wif-1 and hdpr-1. La p\u00e9rdida funcional de estos antagonistas puede contribuir a la activaci\u00f3n de la v\u00eda y producir la leucemog\u00e9nesis a trav\u00e9s de la desregulaci\u00f3n de la proliferaci\u00f3n celular y diferenciaci\u00f3n. por otra parte, wnt5a, se ha postulado como un posible gen supresor de tumores, ya que suprime la expresi\u00f3n de ciclina d1, inhibiendo as\u00ed la proliferaci\u00f3n de las c\u00e9lulas b.  adem\u00e1s, uno de los principales mecanismos de silencio transcripcional de genes supresores de tumores cl\u00e1sicos en lal es la hipermetilaci\u00f3n de islas cpg situadas en los promotores, por lo que, en este trabajo, hemos comparado el patr\u00f3n de metilaci\u00f3n del promotor de los inhibidores de la v\u00eda wnt y de wnt5a en l\u00edneas de lal v\u00edrgenes y tras ser tratadas con agentes desmetilantes. Adem\u00e1s, los resultados obtenidos se han verificado en una cohorte de pacientes diagnosticados de novo de lal mediante pcr espec\u00edfica de metilaci\u00f3n, secuenciaci\u00f3n y an\u00e1lisis de expresi\u00f3n por pcr cuantitativa en tiempo real, confirmando nuestra hip\u00f3tesis de trabajo, ya que demostramos que la regulaci\u00f3n epigen\u00e9tica de los inhibidores de la v\u00eda wnt y de wnt5a contribuyen a la activaci\u00f3n constitutiva de la misma en la lal y por tanto constituyen un mecanismo importante en la g\u00e9nesis de este tipo de leucemia, adem\u00e1s la desregulaci\u00f3n de esta v\u00eda establece un subgrupo de pacientes con un significativo peor pron\u00f3stico y podr\u00eda constituir la base racional para el empleo de agentes desmetilantes o de nuevos f\u00e1rmacos, cuyo mecanismo de acci\u00f3n sea la inhibici\u00f3n de la v\u00eda wnt, para el tratamiento de la lal, pudiendo esta v\u00eda constituir una diana terap\u00e9utica molecular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Relacion epigenetica  de la via wnt en la leucemia aguda linfobl\u00e1stica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Relacion epigenetica  de la via wnt en la leucemia aguda linfobl\u00e1stica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Vanesa Martin Palanco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/10\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Rom\u00e1n G\u00f3mez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Perez jimenez <\/li>\n<li>xabier Aguirre ena (vocal)<\/li>\n<li>Francisco Mart\u00edn bermudo (vocal)<\/li>\n<li>ismael Bu\u00f1o borde (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vanesa Martin Palanco La v\u00eda wnt constituye un regulador cr\u00edtico en los procesos de renovaci\u00f3n celular de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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