{"id":96547,"date":"2018-03-11T10:16:48","date_gmt":"2018-03-11T10:16:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-deplecion-estrogenica-o-androgenica-y-del-tratamiento-con-pth-sobre-la-integridad-osea-en-un-modelo-experimental-en-rata\/"},"modified":"2018-03-11T10:16:48","modified_gmt":"2018-03-11T10:16:48","slug":"efectos-de-la-deplecion-estrogenica-o-androgenica-y-del-tratamiento-con-pth-sobre-la-integridad-osea-en-un-modelo-experimental-en-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/medicina-interna\/efectos-de-la-deplecion-estrogenica-o-androgenica-y-del-tratamiento-con-pth-sobre-la-integridad-osea-en-un-modelo-experimental-en-rata\/","title":{"rendered":"Efectos de la depleci\u00f3n estrog\u00e9nica o androg\u00e9nica y del tratamiento con pth sobre la integridad \u00f3sea, en un modelo experimental en rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mercedes Montero Escobar <\/strong><\/h2>\n<p>La calidad \u00f3sea viene determinada por una serie de factores diversos entre los que presentan especial importancia la propia densidad mineral \u00f3sea (dmo), el remodelado \u00f3seo, la microestructura trabecular y cortical, y las propiedades biomec\u00e1nicas del hueso. el objetivo de este trabajo ha sido el estudio de las variaciones producidas por la ovariectom\u00eda (ovx) o la orquidectom\u00eda (orx) sobre estos factores, as\u00ed como los efectos producidos por la administraci\u00f3n de pth (4\u00c2\u00bfg\/kg\/d\u00eda) v\u00eda subcut\u00e1nea; tanto a nivel preventivo como de tratamiento de una p\u00e9rdida de masa \u00f3sea. en esta tesis hemos demostrado que tanto la ovx como la orx producen alteraciones en la calidad del hueso, y que estas alteraciones son m\u00e1s graves en el caso de la depleci\u00f3n estrog\u00e9nica que en el caso de la depleci\u00f3n androg\u00e9nica. Las ratas orx poseen mecanismos de adaptaci\u00f3n a nivel de hueso cortical que les protegen, al menos durante un tiempo, frente a la p\u00e9rdida de masa \u00f3sea. adem\u00e1s, una dosis de pth (1-34) de 4\u00c2\u00bfg\/kg\/d\u00eda, administrada durante 2.5 meses, es suficiente para prevenir totalmente los efectos producidos por la orx y parcialmente, los efectos producidos por la ovx. Sin embargo, esta misma dosis administrada a ratas con una p\u00e9rdida de masa \u00f3sea muy marcada, tras 6 meses desde que se realizara la cirug\u00eda, no es capaz de recuperar el volumen trabecular perdido ni en el caso de la ovx ni en el de la orx; aunque los efectos en este \u00faltimo si se aprecian. Los resultados obtenidos tras el tratamiento con pth de una p\u00e9rdida de masa \u00f3sea profunda, sugieren que debe existir un l\u00edmite en cuanto a p\u00e9rdida de volumen \u00f3seo a partir del cual un retraso en el tratamiento con pth provoca un efecto anab\u00f3lico insuficiente.  bone quality is determined by a variety of factors, among which bone mineral density (dmo), bone remodelling, trabecular and cortical microstructure, and biomechanical properties of bone have special importance.  the purpose of this work has been to study changes produced by ovariectomy and orchidectomy on these factors, and the effects produced by subcutaneous pth administration (4\u00c2\u00bfg\/kg\/day), at a preventive and treatment level. this thesis demonstrated that both ovariectomy and orchidectomy produced significant alterations in bone quality, and that these alterations are more serious in the case of estrogen lack than androgen lack. Orx rats have mechanisms of adjustment in cortical-bone, that protect them, at least during a time, opposite to the loss of bone mass. in addition, (1-34)pth at a dose of 4\u00c2\u00bfg\/kg\/day, administered for 2.5 months, is sufficient to totally prevent the effects produced by orx and, partially, the effects produced by ovx. Nevertheless, the same dose administered to rats with a marked bone loss, 6 months after surgery, is not capable of recovering the loss in trabecular volume not in case of the ovx not in that of the orx; although there are some effects in the orx. The results obtained after the pth treatment of deep bone loss suggest that a limit exist in the level of bone loss from which a delay in the beginning of pth treatment produces an insufficient anabolic effect of pth.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de la depleci\u00f3n estrog\u00e9nica o androg\u00e9nica y del tratamiento con pth sobre la integridad \u00f3sea, en un modelo experimental en rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de la depleci\u00f3n estrog\u00e9nica o androg\u00e9nica y del tratamiento con pth sobre la integridad \u00f3sea, en un modelo experimental en rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mercedes Montero Escobar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/10\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel D\u00edaz Curiel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Fern\u00e1ndez guerrero <\/li>\n<li>Mar\u00eda teresa Carrascal morillo (vocal)<\/li>\n<li>Jos\u00e9 Fernando Marin diez (vocal)<\/li>\n<li>santos Casta\u00f1eda  sanz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mercedes Montero Escobar La calidad \u00f3sea viene determinada por una serie de factores diversos entre los que 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