{"id":96552,"date":"2018-03-11T10:16:48","date_gmt":"2018-03-11T10:16:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/prediccion-de-la-respuesta-al-tratamiento-con-doxorrubicina-o-docetaxel-en-cancer-de-mama-mediante-modelos-pronosticos-unigenicos-y-poligenicos\/"},"modified":"2018-03-11T10:16:48","modified_gmt":"2018-03-11T10:16:48","slug":"prediccion-de-la-respuesta-al-tratamiento-con-doxorrubicina-o-docetaxel-en-cancer-de-mama-mediante-modelos-pronosticos-unigenicos-y-poligenicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/prediccion-de-la-respuesta-al-tratamiento-con-doxorrubicina-o-docetaxel-en-cancer-de-mama-mediante-modelos-pronosticos-unigenicos-y-poligenicos\/","title":{"rendered":"Predicci\u00f3n de la respuesta al tratamiento con doxorrubicina o docetaxel en c\u00e1ncer de mama mediante modelos pron\u00f3sticos unig\u00e9nicos y polig\u00e9nicos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Atocha Romero Alfonso <\/strong><\/h2>\n<p>Null predicci\u00f3n de la respuesta al tratamiento con doxorrubicina y docetaxel mediante modelos pron\u00f3sticos unig\u00e9nicos y polig\u00e9nicos.  en esta tesis doctoral se eval\u00faa el posible papel predictivo de: la deleci\u00f3n homocigota de gstm1 en sangre, la deleci\u00f3n ho mocigota de gstt1 en sangre, el snp a342g de gstp1 en sangre, la expresi\u00f3n de top2a en tejido tumoral, la alteraciones en el n\u00famero de copias de top2a  en tejido tumoral y el subtipo gen\u00f3mico, en 227 pacientes  diagnosticadas de c\u00e1ncer de mama localm ente avanzado tratadas en monoterapia con doxorrubicina o docetaxel. nuestras conclusiones m\u00e1s relevantes son:  1.\tQue la deleci\u00f3n homocigota de gstt1 o gstm1 se asocia, d\u00e9bilmente, a la respuesta a doxorrubicina pero no a la respuesta a docetaxel. 2 .\tQue ni la expresi\u00f3n ni las alteraciones en el n\u00famero de copias de top2a predicen la respuesta a ninguno de los dos f\u00e1rmacos. 3.\tQue los distintos subtipos gen\u00f3micos presentan distintas quimiosensibilidades. As\u00ed,   los tumores basales los m\u00e1s sensib les al docetaxel y no responden a doxorrubicina, los tumores claudin-low son aparentemente los m\u00e1s sensibles a doxorrubicina, los tumores her2-enriched son moderadamente sensibles a ambos f\u00e1rmacos y los tumores luminales a y b resisten a ambos tratam ientos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Predicci\u00f3n de la respuesta al tratamiento con doxorrubicina o docetaxel en c\u00e1ncer de mama mediante modelos pron\u00f3sticos unig\u00e9nicos y polig\u00e9nicos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Predicci\u00f3n de la respuesta al tratamiento con doxorrubicina o docetaxel en c\u00e1ncer de mama mediante modelos pron\u00f3sticos unig\u00e9nicos y polig\u00e9nicos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Atocha Romero Alfonso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/10\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Trinidad Cald\u00e9s Llopis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  pilar (secretario) Iniesta serrano <\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Atocha Romero Alfonso Null predicci\u00f3n de la respuesta al tratamiento con doxorrubicina y docetaxel mediante modelos pron\u00f3sticos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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