{"id":96643,"date":"2018-03-11T10:16:57","date_gmt":"2018-03-11T10:16:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/biomarcadores-de-proyeccion-pronostica-en-astrocitomas-de-alto-grado-de-origen-humano\/"},"modified":"2018-03-11T10:16:57","modified_gmt":"2018-03-11T10:16:57","slug":"biomarcadores-de-proyeccion-pronostica-en-astrocitomas-de-alto-grado-de-origen-humano","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/neurocirugia\/biomarcadores-de-proyeccion-pronostica-en-astrocitomas-de-alto-grado-de-origen-humano\/","title":{"rendered":"Biomarcadores de proyeccion pronostica en astrocitomas de alto grado de origen humano"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alejandro Carrasco Gonzalez <\/strong><\/h2>\n<p>Los tumores cerebrales de estirpe astrocitaria de alto grado (grados iii y iv de la oms) son los m\u00e1s frecuentes dentro de los primarios del enc\u00e9falo y presentan muy mal pron\u00f3stico. Los factores pron\u00f3sticos m\u00e1s importantes son la edad en el momento del diagn\u00f3stico y la histopatolog\u00eda. Existen marcadores biol\u00f3gicos (ki-67, p53, egfr y vegf) de marcada relevancia en el desarrollo y crecimiento de estas neoplasias cuyo valor pron\u00f3stico no est\u00e1 a\u00fan aclarado. Se han desarrollado t\u00e9cnicas de laboratorio para su detecci\u00f3n mediante inmunohistoqu\u00edmica que han sido ampliamente difundidas en el proceso diagn\u00f3stico rutinario. Se presenta una serie de casos de astrocitomas de alto grado recogidos prospectivamente en los que se realizaron estudios de inmunohistoqu\u00edmica y se registraron las caracter\u00edsticas cl\u00ednico-biol\u00f3gicas de cada caso. Se realiz\u00f3 un estudio de supervivencia con relaci\u00f3n a las diferentes variables recogidas con el objetivo de encontrar nuevos marcadores con valor pron\u00f3stico. Asimismo, se estudiaron las correlaciones entre los diferentes par\u00e1metros. La elaboraci\u00f3n de un registro de tumores se vio complementada con la puesta en marcha de un programa de donantes neurooncol\u00f3gico (do.No.) Que permite recoger cerebros de pacientes fallecidos por un astrocitoma de alto grado con el objetivo de acceder al estudio del \u00e1rea peritumoral y \u00e1reas remotas, as\u00ed como tener acceso a los efectos biol\u00f3gicos inducidos por los tratamientos administrados y poder poner e marcha t\u00e9cnicas de estudio sobre dna y prote\u00ednas tumorales. Se obtuvieron relaciones significativas entre la determinaci\u00f3n de egfr y ki-67 con la supervivencia. Se elabor\u00f3 una colecci\u00f3n de cerebros de pacientes neurooncol\u00f3gicos consolidando el programa do.No. Y se defini\u00f3 el escaso valor pron\u00f3stico de las determinaciones inmunohistoqu\u00edmicas de marcadores biol\u00f3gicos, aunque su estudio permite dise\u00f1ar y poner en marcha nuevas terapias apoyadas en el mejor conocimiento de la biolog\u00eda tumoral.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Biomarcadores de proyeccion pronostica en astrocitomas de alto grado de origen humano<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Biomarcadores de proyeccion pronostica en astrocitomas de alto grado de origen humano <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alejandro Carrasco Gonzalez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/10\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Mar\u00eda Garibi Undabarrena<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Vaquero crespo <\/li>\n<li>joaquin Lucena romero (vocal)<\/li>\n<li>Francisco Javier Bilbao ercoreca (vocal)<\/li>\n<li>Miguel Gelabert gonz\u00e1lez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alejandro Carrasco Gonzalez Los tumores cerebrales de estirpe astrocitaria de alto grado (grados iii y iv de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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