{"id":96655,"date":"2018-03-11T10:16:57","date_gmt":"2018-03-11T10:16:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/funciones-de-los-receptores-de-estrogenos-en-neuronas-interaccion-con-otras-va%c2%adas-intracelulares-e-implicacion-en-morfologia-neuronal\/"},"modified":"2018-03-11T10:16:57","modified_gmt":"2018-03-11T10:16:57","slug":"funciones-de-los-receptores-de-estrogenos-en-neuronas-interaccion-con-otras-va%c2%adas-intracelulares-e-implicacion-en-morfologia-neuronal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-molecular\/funciones-de-los-receptores-de-estrogenos-en-neuronas-interaccion-con-otras-va%c2%adas-intracelulares-e-implicacion-en-morfologia-neuronal\/","title":{"rendered":"Funciones de los receptores de estrogenos en neuronas: interaccion con otras v\u00edas intracelulares e implicacion en morfolog\u00eda neuronal."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Olga Varea Abbad <\/strong><\/h2>\n<p>\u00edndice&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;1 abreviaturas&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..5 introducci\u00f3n&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;11 1-mecanismos moleculares que controlan el desarrollo neuronal&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;13 1.1. Neuritog\u00e9nesis-polarizaci\u00f3n neuronal-sistemas modelo&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..13 1.2. Mecanismos que regulan la neuritog\u00e9nesis y la polaridad neuronal&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.. 15 1.3. V\u00eda de activaci\u00f3n de pi3k, papel en desarrollo neuronal. Dianas de akt y otras rutas&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;16 2-estr\u00f3genos&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;27 2.1. Ruta de s\u00edntesis y metabolismo de estradiol&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.27 2.2. Antagonistas estrog\u00e9nicos&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.29 3-funci\u00f3n de los estr\u00f3genos en cerebro&#8230;&#8230;&#8230;&#8230;.30 3.1.Efecto de los estr\u00f3genos en el desarrollo neuronal&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;30 3.2. Efecto de los estr\u00f3genos en neuronas maduras: excitabilidad de la membrana&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;30 3.3. Papel de los estr\u00f3genos en funciones cognitivas&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;. 31 3.4. Neuroprotecci\u00f3n&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;32 4-receptores de estr\u00f3genos&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;33 4.1. Er\u00c2\u00bf y er\u00edY&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.33 4.2. Receptor gpr-30&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;37 4.3. Expresi\u00f3n de los receptores de estr\u00f3genos en cerebro&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.38 4.4. Localizaci\u00f3n de los receptores de estr\u00f3genos&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.38 4.5. Modificaciones post-traduccionales de los receptores de estr\u00f3genos&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.40 4.6. Sistemas de estudio para los receptores de estr\u00f3genos&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..41 5-mecanismos de acci\u00f3n de los estr\u00f3genos&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.42 5.1. Se\u00f1alizaci\u00f3n a trav\u00e9s del receptor gpr-30&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.42 5.2. Acci\u00f3n nuclear o  acci\u00f3n gen\u00f3mica a trav\u00e9s de er\u00c2\u00bf y er\u00edY&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;43 5.3. V\u00edas de se\u00f1alizaci\u00f3n citoplasm\u00e1ticas o de acci\u00f3n r\u00e1pida mediante los ers &#8230;45 objetivos&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230; 47 3 4 materiales y m\u00e9todos&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.51 resultados&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;69 &#8211; expresi\u00f3n, localizaci\u00f3n e implicaci\u00f3n de los receptores de estr\u00f3genos en el desarrollo de neuronas en cultivo&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.71 1. Expresi\u00f3n de los receptores de estr\u00f3genos en neuronas primarias de corteza&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..71 2. Localizaci\u00f3n de los receptores de estr\u00f3genos en neuronas de corteza e hipocampo&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;73 3. An\u00e1lisis de la funci\u00f3n de los receptores de estr\u00f3genos en el desarrollo neuronal&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..75 &#8211; se\u00f1alizaci\u00f3n intracelular mediada por estradiol&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;85 4. Activaci\u00f3n de la v\u00eda pi3k-akt por estradiol&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..85 5. Estradiol promueve la activaci\u00f3n de mtorc1&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.86 6. Inhibici\u00f3n de gsk3 por estradiol. Efecto sobre \u00edY-catenina&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;88 7. Efecto de estradiol sobre la actividad mapk &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.113 8. Papel de estradiol sobre pi3k-akt-gsk3 en desarrollo neuronal&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..114 &#8211; control de las v\u00edas de se\u00f1alizaci\u00f3n mediadas por estradiol sobre la morfolog\u00eda neuronal&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..117 8. Efecto de la sobreexpresi\u00f3n de \u00edY-catenina en la longitud axonal regulada por estr\u00f3genos..117 9. An\u00e1lisis de la implicaci\u00f3n de la actividad rheb\/mtorc1 en el desarrollo neuronal mediado por ers&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;119 10. Implicaci\u00f3n de la din\u00e1mica de actina en el crecimiento de neuritas mediado por ers&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.1<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Funciones de los receptores de estrogenos en neuronas: interaccion con otras v\u00edas intracelulares e implicacion en morfolog\u00eda neuronal.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Funciones de los receptores de estrogenos en neuronas: interaccion con otras v\u00edas intracelulares e implicacion en morfolog\u00eda neuronal. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Olga Varea Abbad <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/10\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Wandosell Jurado<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: paola Bovolenta nicolao <\/li>\n<li>Jos\u00e9 Luis Trejo p\u00e9rez (vocal)<\/li>\n<li>i\u00f1igo Azcoitia elias (vocal)<\/li>\n<li>Miguel D\u00edaz hern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Olga Varea Abbad \u00edndice&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;1 abreviaturas&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..5 introducci\u00f3n&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;11 1-mecanismos moleculares que controlan el desarrollo neuronal&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;13 1.1. Neuritog\u00e9nesis-polarizaci\u00f3n neuronal-sistemas modelo&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..13 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483],"tags":[29533,36247,189611,51156,198382,29565],"class_list":["post-96655","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","tag-francisco-wandosell-jurado","tag-inigo-azcoitia-elias","tag-jose-luis-trejo-perez","tag-miguel-diaz-hernandez","tag-olga-varea-abbad","tag-paola-bovolenta-nicolao"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/96655","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=96655"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/96655\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=96655"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=96655"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=96655"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}