{"id":96674,"date":"2018-03-11T10:16:57","date_gmt":"2018-03-11T10:16:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-expresion-de-la-oxido-na%c2%adtrico-sintasa-inducible-por-receptores-de-rna-de-doble-cadena-en-macrofagos\/"},"modified":"2018-03-11T10:16:57","modified_gmt":"2018-03-11T10:16:57","slug":"regulacion-de-la-expresion-de-la-oxido-na%c2%adtrico-sintasa-inducible-por-receptores-de-rna-de-doble-cadena-en-macrofagos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-inmunologica\/regulacion-de-la-expresion-de-la-oxido-na%c2%adtrico-sintasa-inducible-por-receptores-de-rna-de-doble-cadena-en-macrofagos\/","title":{"rendered":"Regulaci\u00f3n de la expresion de la \u00f3xido n\u00edtrico sintasa inducible por receptores de rna de doble cadena en macr\u00f3fagos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Pindado Rodr\u00edguez <\/strong><\/h2>\n<p>El rna de doble cadena es un producto de la replicaci\u00f3n viral capaz de inducir una respuesta inflamatoria cuando es reconocida por las c\u00e9lulas fagoc\u00edticas. En este proyecto de tesis se estudiar\u00e1 la fosfolipasa a2 citos\u00f3lica del grupo iva (cpla2\u00c2\u00bf) como un efector de la respuesta antiviral de los macr\u00f3fagos.   el tratamiento de la l\u00ednea celular macrof\u00e1gica murina raw 264.7 con \u00e1cido poliinos\u00ednico-policitid\u00edlico (poly i-c, un an\u00e1logo de rna de doble cadena) promueve la liberaci\u00f3n de acido araquid\u00f3nico (aa) que es convertido en prostaglandina e2 (pge2) por la enzima ciclooxigenasa-2 (cox-2). Estos procesos son bloqueados por pyrrofenona, inhibidor selectivo de la cpla2\u00c2\u00bf, se\u00f1alando a esta enzima como el efector implicado. De acuerdo con estas observaciones, el estado  de fosforilaci\u00f3n de la cpla2\u00c2\u00bf  aumenta despu\u00e9s del tratamiento celular con poly i-c. La inhibici\u00f3n de la expresi\u00f3n y la actividad de la cpla2\u00c2\u00bf, bien por sirna o por pyrrofenona, conduce a la inhibici\u00f3n de la expresi\u00f3n del gen de la \u00f3xido n\u00edtrico sintasa inducible (inos). Adem\u00e1s la producci\u00f3n de pge-2 derivada de cox-2 parece participar en la expresi\u00f3n de inos, ya que la inhibici\u00f3n de la expresi\u00f3n de cox-2 por rna de interferencia tambi\u00e9n conduce a la inhibici\u00f3n de la expresi\u00f3n de inos y este efecto es restaurado con la adici\u00f3n ex\u00f3gena de pge2. finalmente la eliminaci\u00f3n de toll-like receptor 3 (tlr3) por sirna, inhibe la expresi\u00f3n de cox-2, la generaci\u00f3n de pge2 y la inducci\u00f3n de inos por poly i-c.  colectivamente, estos hallazgos sugerir\u00edan un modelo durante la activaci\u00f3n del macr\u00f3fago en respuesta a rna de doble cadena, en el que el reconocimiento de esta mol\u00e9cula por el receptor tlr3 lleva a la movilizaci\u00f3n de aa mediada por cpla2\u00c2\u00bf y la producci\u00f3n de pge2 mediada por cox-2, que cooperan para inducir la expresi\u00f3n de inos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n de la expresion de la \u00f3xido n\u00edtrico sintasa inducible por receptores de rna de doble cadena en macr\u00f3fagos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n de la expresion de la \u00f3xido n\u00edtrico sintasa inducible por receptores de rna de doble cadena en macr\u00f3fagos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Pindado Rodr\u00edguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/10\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Balsinde Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: andr\u00e9s Alonso Garc\u00eda <\/li>\n<li>isabel Varela nieto (vocal)<\/li>\n<li>Juan  Manuel Zapata hernandez (vocal)<\/li>\n<li>Manuel Izquierdo pastor (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Pindado Rodr\u00edguez El rna de doble cadena es un producto de la replicaci\u00f3n viral capaz de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2148,12451],"tags":[95305,44785,119306,198407,146730,38045],"class_list":["post-96674","post","type-post","status-publish","format-standard","hentry","category-bioquimica-inmunologica","category-valladolid","tag-andres-alonso-garcia","tag-isabel-varela-nieto","tag-jesus-balsinde-rodriguez","tag-jose-pindado-rodriguez","tag-juan-manuel-zapata-hernandez","tag-manuel-izquierdo-pastor"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/96674","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=96674"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/96674\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=96674"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=96674"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=96674"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}