{"id":96694,"date":"2018-03-11T10:16:57","date_gmt":"2018-03-11T10:16:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-qua%c2%admica-de-rutas-de-senalizacion-celular-optimizacion-de-compuestos-hits-identificados-a-traves-de-quimiotecas\/"},"modified":"2018-03-11T10:16:57","modified_gmt":"2018-03-11T10:16:57","slug":"modulacion-qua%c2%admica-de-rutas-de-senalizacion-celular-optimizacion-de-compuestos-hits-identificados-a-traves-de-quimiotecas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/modulacion-qua%c2%admica-de-rutas-de-senalizacion-celular-optimizacion-de-compuestos-hits-identificados-a-traves-de-quimiotecas\/","title":{"rendered":"Modulaci\u00f3n qu\u00edmica de rutas de se\u00f1alizaci\u00f3n celular: optimizaci\u00f3n de compuestos hits identificados a trav\u00e9s de quimiotecas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Alejandra Moure Fern\u00e1ndez <\/strong><\/h2>\n<p>El dise\u00f1o de mol\u00e9culas dirigidas al reconocimiento de superficies proteicas y que posean la capacidad de modular interacciones prote\u00edna-prote\u00edna se considera uno de los mayores retos de la qu\u00edmica m\u00e9dica.  la modulaci\u00f3n qu\u00edmica de tr\u00edmeros de n-alquilglicinas (peptoides) hits identificados frente a diferentes dianas, ha conducido en esta tesis a la s\u00edntesis y el estudio de familias de peptidomim\u00e9ticos que constituyen mol\u00e9culas conformacionalmente restringidas derivadas de aquellos peptoides.  dado que la restricci\u00f3n conformacional en los compuestos no es completa, ya que la mol\u00e9cula contiene una amida exoc\u00edclica, en este trabajo se discute el estudio estructural realizado sobre estos peptidomim\u00e9ticos a trav\u00e9s de rmn y modelizaci\u00f3n computacional. A su vez tambi\u00e9n se ha estudiado la s\u00edntesis de los compuestos de forma enantiopura ya que el conocimiento de la orientaci\u00f3n tridimensional de los grupos funcionales es fundamental para una correcta adaptaci\u00f3n a su diana biol\u00f3gica. finalmente, se describen los resultados obtenidos en la b\u00fasqueda de mol\u00e9culas que inhiban la apoptosis, as\u00ed como los compuestos con capacidad inhibidora de la se\u00f1alizaci\u00f3n mediada por ubc13-uev1, \u00e9stos \u00faltimos con inter\u00e9s como antitumorales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulaci\u00f3n qu\u00edmica de rutas de se\u00f1alizaci\u00f3n celular: optimizaci\u00f3n de compuestos hits identificados a trav\u00e9s de quimiotecas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulaci\u00f3n qu\u00edmica de rutas de se\u00f1alizaci\u00f3n celular: optimizaci\u00f3n de compuestos hits identificados a trav\u00e9s de quimiotecas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Alejandra Moure Fern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/10\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angel Messeguer Peypoch<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rosa Mar\u00eda Ortu\u00f1o mingarro <\/li>\n<li>Jos\u00e9 Luis Mascare\u00f1as cid (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Alejandra Moure Fern\u00e1ndez El dise\u00f1o de mol\u00e9culas dirigidas al reconocimiento de superficies proteicas y que posean [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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