{"id":96714,"date":"2018-03-11T10:17:03","date_gmt":"2018-03-11T10:17:03","guid":{"rendered":""},"modified":"2018-03-11T10:17:03","modified_gmt":"2018-03-11T10:17:03","slug":"analisis-del-efecto-terapeutico-y-los-mecanismos-moleculares-inducidos-por-vectores-virales-que-expresan-el-factor-de-crecimiento-similar-a-la-insulina-de-tipo-i-igf-i-en-el-tratamiento-de-la-cirros","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/analisis-del-efecto-terapeutico-y-los-mecanismos-moleculares-inducidos-por-vectores-virales-que-expresan-el-factor-de-crecimiento-similar-a-la-insulina-de-tipo-i-igf-i-en-el-tratamiento-de-la-cirros\/","title":{"rendered":"An\u00e1lisis del efecto terap\u00e9utico y los mecanismos moleculares inducidos por vectores virales que expresan el factor de crecimiento similar a la insulina de tipo i (igf-i) en el tratamiento de la cirrosis hep\u00e1tica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luciano Mat\u00edas Sobrevals <\/strong><\/h2>\n<p>Previous studies have demostrated that the administration of recombinant igf-i protein is effective in the treatment of liver cirrhosis. However, the short half life of igf-i in serum and the high price of recombinant igf-i protein production, make this treatment exceedingly costly. Therefore, we have analyzed the therapeutic effect in liver cirrhosis of igf-i gene transfer using viral vectors. We have used recombinant viral vectors expressing rat igf-i based on simian virus 40 (rsvigf-i) or adeno-associated vectors (raavigf-i). We have inyected these vectors before or after cirrhosis induction in rats. Cirrhosis has been developed by intragastric administration of ccl4. Both pretreatment and treatment of liver cirrhosis with rsvigf-i or raavigf-i induced a curative process that resulted in improved liver functionality and decreased liver fibrosis. This therapeutic effect seems mediated by the igf-i-dependent induction of cytoprotective and antifibrogenic molecules and the inhibition of profibrogenic factors. Thus, igf-i expression reprograms the liver from a \u00c2\u00bfscar formation\u00c2\u00bf program, which leads to cirrhosis, to a \u00c2\u00bftissue repair\u00c2\u00bf circuit that favours cirrhosis regression. Surprisingly, therapy was less efficient when rsvigf-i or high doses of aavigf-i were used. None of the vectors showed toxic effects in cirrhotic or healthy animals. The therapeutic effects observed with low doses of aav vectors expressing igf-i allows us to suggest that these vectors could base a useful therapy for patients that deteriorate in the waiting list for liver transplantation or for those patients non-suitable for liver transplant.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis del efecto terap\u00e9utico y los mecanismos moleculares inducidos por vectores virales que expresan el factor de crecimiento similar a la insulina de tipo i (igf-i) en el tratamiento de la cirrosis hep\u00e1tica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis del efecto terap\u00e9utico y los mecanismos moleculares inducidos por vectores virales que expresan el factor de crecimiento similar a la insulina de tipo i (igf-i) en el tratamiento de la cirrosis hep\u00e1tica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luciano Mat\u00edas Sobrevals <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/10\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Purificacion Fortes Alonso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ignacio Torres alem\u00e1n <\/li>\n<li>cristina Fillat fonts (vocal)<\/li>\n<li>ramon Bataller alberola (vocal)<\/li>\n<li>Jorge  augusto Quiroga vilas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luciano Mat\u00edas Sobrevals Previous studies have demostrated that the administration of recombinant igf-i protein is effective in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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