{"id":9681,"date":"1995-12-05T00:00:00","date_gmt":"1995-12-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/12\/05\/desarrollo-de-un-modelo-in-vitro-para-el-estudio-del-potencial-fotosensibilizador-de-nuevos-farmacos-en-humanos\/"},"modified":"1995-12-05T00:00:00","modified_gmt":"1995-12-05T00:00:00","slug":"desarrollo-de-un-modelo-in-vitro-para-el-estudio-del-potencial-fotosensibilizador-de-nuevos-farmacos-en-humanos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/desarrollo-de-un-modelo-in-vitro-para-el-estudio-del-potencial-fotosensibilizador-de-nuevos-farmacos-en-humanos\/","title":{"rendered":"Desarrollo de un modelo in vitro para el estudio del potencial fotosensibilizador de nuevos farmacos en humanos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luis Antonio Martinez Lopez <\/strong><\/h2>\n<p>Un sistema ideal para evaluar el potencial fotosensibilizador de farmacos debe ser simple, reproducir las propiedades de la piel, detectar los efectos de especies de corta vida y fotoproductos estables, disponer de parametros adecuados para evaluar los efectos toxicos y ser reproducible.Se pretende estudiar la idoneidad de sistemas celulares para evaluar la capacidad fotosensibilizadora de farmacos, estudiar los mecanismos moleculares de la fotosensibilizacion y llevar a cabo estudios estructura-actividad que permitan sentar las bases para la prediccion del comportamiento fotosensibilizador de nuevos farmacos. Debido a la gran diversidad estructural de los farmacos fotosensibilizantes, se selecciona como objeto de estudio un grupo homogeneo, los antiinflamatorios no esteroideos derivados del acido 2-fenilpropionico, de reconocido caracter fotosensibilizante. El trabajo comprende su estudio fisicoquimico (irradiacion, separacion y caracterizacion de fotoproductos), evaluacion de los efectos fotobiologicos (toxicidad fotoproductos estables, toxicidad intermedios inestables, toxicidad de especies radicalarias derivadas de los farmacos) y el estudio de la fotoalergia inducida por estos farmacos (incluyendo marcaje radioactivo y evaluacion de la capacidad de union a proteinas como indicador del potencial fotoalergenico).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo de un modelo in vitro para el estudio del potencial fotosensibilizador de nuevos farmacos en humanos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo de un modelo in vitro para el estudio del potencial fotosensibilizador de nuevos farmacos en humanos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luis Antonio Martinez Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/05\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Vicente Castells Ripoll<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Franco vera <\/li>\n<li>Rafael Suau suarez (vocal)<\/li>\n<li>gerardus m.j. Beijersbergen  van henegouwen (vocal)<\/li>\n<li>Jaime Primo millo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luis Antonio Martinez Lopez Un sistema ideal para evaluar el potencial fotosensibilizador de farmacos debe ser simple, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,189,401],"tags":[32936,6779,10754,32935,11638,2512],"class_list":["post-9681","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacodinamia","category-toxicologia","tag-gerardus-m-j-beijersbergen-van-henegouwen","tag-jaime-primo-millo","tag-jose-vicente-castells-ripoll","tag-luis-antonio-Martinez-lopez","tag-luis-franco-vera","tag-rafael-suau-suarez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/9681","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=9681"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/9681\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=9681"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=9681"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=9681"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}