{"id":96882,"date":"2018-03-11T10:17:16","date_gmt":"2018-03-11T10:17:16","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cancer-de-mama-estadiaje-molecular-del-ganglio-centinela\/"},"modified":"2018-03-11T10:17:16","modified_gmt":"2018-03-11T10:17:16","slug":"cancer-de-mama-estadiaje-molecular-del-ganglio-centinela","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cancer-de-mama-estadiaje-molecular-del-ganglio-centinela\/","title":{"rendered":"C\u00e1ncer de mama: estadiaje molecular del ganglio centinela"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Josefa Isabel Campo Gesto <\/strong><\/h2>\n<p>El tratamiento quir\u00fargico del c\u00e1ncer de mama ha incluido tradicionalmente la disecci\u00f3n axilar para la detecci\u00f3n de met\u00e1stasis axilares, ya que \u00e9ste es el factor predictivo m\u00e1s importante de que disponemos. Sin embargo, existe otra forma de obtener lo s mismos resultados sin a\u00f1adir a la paciente la morbillidad que ocasiona la disecci\u00f3n axilar completa: se trata de la biopsia del ganglio centinela, t\u00e9cnica que ha revolucionado el tratamiento del c\u00e1ncer de mama en la \u00faltima d\u00e9cada 1.  la t\u00e9cnica del  ganglio centinela en el carcinoma de mama estadios i y ii, es ya una t\u00e9cnica instaurada: s\u00f3lo en el caso de que el ganglio centinela resulte positivo para tumor, se realiza la disecci\u00f3n axilar, lo que reduce las linfadenectom\u00edas a un 30  aproximadam ente en estos estadios2.  la principal tarea para el anatomopat\u00f3logo es investigar posibles met\u00e1stasis en el ganglio centinela. Esta investigaci\u00f3n debe ser realizada m\u00e1s exhaustivamente, si cabe,  de lo habitual, puesto que un falso negativo puede ha cer que se omita la disecci\u00f3n axilar y por lo tanto no lograr un buen control locorregional, objetivo primordial de la cirug\u00eda.    hasta hace alg\u00fan tiempo, el estudio de todos los ganglios disecados comprend\u00eda 2 \u00f3 3 secciones de cada ganglio, que se te\u00f1\u00edan con hematoxilina-eosina siendo muy dif\u00edcil realizar estudios exhaustivos de todos ellos, \u00f3 dirigir el esfuerzo diagn\u00f3stico a uno \u00f3 dos ganglios espec\u00edficos3.  hoy en d\u00eda esto es posible localizando el ganglio centinela, primer ganglio de drena je de la mama en una paciente espec\u00edfica en un momento dado, con una m\u00e1xima fiabilidad y m\u00ednima morbilidad.  para estudiar el ganglio centinela, adem\u00e1s, se pueden emplear varios m\u00e9todos:  a)\tmorfol\u00f3gicos:  1.\tHistolog\u00eda cl\u00e1sica (h\/e). 2.\tInmunohistoq u\u00edmica. 3.\tAn\u00e1lisis de secciones seriadas m\u00faltiples congeladas 4.\tCitolog\u00edas b)\tno morfol\u00f3gicos: 1.\tCitometr\u00eda de flujo 2.\tAn\u00e1lisis molecular  el estudio del ganglio centinela utilizando inmunohistoqu\u00edmica constituye un indudable avance en el diagn\u00f3s tico de met\u00e1stasis axilares, que incrementa el porcentaje (hasta en un 10-20 ) de detecci\u00f3n frente al estudio rutinario con hematoxilina-eosina. Su estudio ha desembocado en la nueva clasificaci\u00f3n de tumores tnm en que se incluye la categor\u00eda iqm  in dicando que la met\u00e1stasis hallada lo ha sido por m\u00e9todos de inmunohistoqu\u00edmica.4  el estudio del ganglio centinela utilizando an\u00e1lisis molecular: se trata de una t\u00e9cnica de elevada sensibilidad (incremento de un 84  a un 93 ), fiabilidad (incremento<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>C\u00e1ncer de mama: estadiaje molecular del ganglio centinela<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 C\u00e1ncer de mama: estadiaje molecular del ganglio centinela <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Josefa Isabel Campo Gesto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/10\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Vidart Arag\u00f3n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Bull\u00f3n sopelana <\/li>\n<li>pilar Miranda serrano (vocal)<\/li>\n<li>enrique Iglesias goy (vocal)<\/li>\n<li>rogelio Garrido teruel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Josefa Isabel Campo Gesto El tratamiento quir\u00fargico del c\u00e1ncer de mama ha incluido tradicionalmente la disecci\u00f3n axilar [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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