{"id":96957,"date":"2009-02-11T00:00:00","date_gmt":"2009-02-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-hsprouty2-interaccion-con-protea%c2%adnas-senalizadoras-y-papel-en-cancer\/"},"modified":"2009-02-11T00:00:00","modified_gmt":"2009-02-11T00:00:00","slug":"estudio-de-hsprouty2-interaccion-con-protea%c2%adnas-senalizadoras-y-papel-en-cancer","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/estudio-de-hsprouty2-interaccion-con-protea%c2%adnas-senalizadoras-y-papel-en-cancer\/","title":{"rendered":"Estudio de hsprouty2: interacci\u00f3n con prote\u00ednas se\u00f1alizadoras y papel en c\u00e1ncer."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Agust\u00edn S\u00e1nchez Rodr\u00edguez <\/strong><\/h2>\n<p>Las prote\u00ednas de la familia sprouty\/spred se han descrito como reguladores de la v\u00eda de se\u00f1alizaci\u00f3n erk, activada por varios factores de crecimiento, como pueden ser egf, fgf, vegf, ngf y otros. Hemos estudiado la interacci\u00f3n de hsprouty2 con distintas prote\u00ednas que participan en la v\u00eda erk\/elk1 y que poseen dominios sh3. Las prote\u00ednas plcgamma1, itsn y grb2 se unen a hsprouty2, aunque dicha interacci\u00f3n no afecta a la manera en que la v\u00eda erk\/elk1 es regulada por hsprouty2. Adem\u00e1s, hemos comprobado que hsprouty2 inhibe la v\u00eda  erk\/elk1 cuando es activada desde balsas lip\u00eddicas. Debido al papel fundamental que juega en la progresi\u00f3n tumoral la v\u00eda erk, tambi\u00e9n hemos estudiado la relevancia de los genes spry\/spred en la progresi\u00f3n tumoral. Hemos comprobado que el silenciamiento de la expresi\u00f3n de hsprouty2 en la l\u00ednea celular sw480 adh, induce su senescencia. Adem\u00e1s, en esta l\u00ednea celular se ha identificado una mutaci\u00f3n puntual en hsprouty2. Tambi\u00e9n hemos comprobado que el gen hsprouty4 tiene hipermetilado su promotor en una l\u00ednea celular derivada de una eritroleucemia, mientras que el gen hspred1 presenta hipermetilaci\u00f3n de su promotor en una l\u00ednea celular derivada de una leucemia linfoide aguda pre-b. Por su parte, la expresi\u00f3n del gen hsprouty2 est\u00e1 silenciada debido a un mecanismo de metilaci\u00f3n de su promotor en una l\u00ednea celular cuyo origen es un  linfoma b difuso. Por \u00faltimo, hemos comprobado que en linfomas b difusos tambi\u00e9n aparece esta alteraci\u00f3n en un 37% de las muestras analizadas, correlacion\u00e1ndose con una menor supervivencia a los cinco a\u00f1os.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de hsprouty2: interacci\u00f3n con prote\u00ednas se\u00f1alizadoras y papel en c\u00e1ncer.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de hsprouty2: interacci\u00f3n con prote\u00ednas se\u00f1alizadoras y papel en c\u00e1ncer. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Agust\u00edn S\u00e1nchez Rodr\u00edguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/11\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Mar\u00eda Rojas Caba\u00f1eros<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Fernandez piqueras <\/li>\n<li>almudena Porras gallo (vocal)<\/li>\n<li>pedro Fern\u00e1ndez salguero (vocal)<\/li>\n<li>carmen Guerrero arroyo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Agust\u00edn S\u00e1nchez Rodr\u00edguez Las prote\u00ednas de la familia sprouty\/spred se han descrito como reguladores de la v\u00eda [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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