{"id":96990,"date":"2009-04-11T00:00:00","date_gmt":"2009-04-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/enteropatia-inflamatoria-en-la-colestasis-extrahepatica-microquirurgi-ca-experimental\/"},"modified":"2009-04-11T00:00:00","modified_gmt":"2009-04-11T00:00:00","slug":"enteropatia-inflamatoria-en-la-colestasis-extrahepatica-microquirurgi-ca-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/enteropatia-inflamatoria-en-la-colestasis-extrahepatica-microquirurgi-ca-experimental\/","title":{"rendered":"Enteropatia inflamatoria en la colestasis extrahep\u00e1tica microquir\u00fargi-ca experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Felipe Vicente Collado <\/strong><\/h2>\n<p>Null los pacientes con colestasis obstructiva sufren una elevada morbi-mortalidad. Esto se debe a las alteraciones hep\u00e1ticas (estructurales y funcionales) y a las alteraciones sist\u00e9micas que se producen como consecuencia de la acumulaci\u00f3n de \u00e1cidos biliar es, bilirrubina y otros solutos colef\u00edlicos en el h\u00edgado y en la sangre. Las alteraciones espl\u00e1cnicas que se producen en ratas con colestasis extrahep\u00e1tica podr\u00edan tener una etiopatogenia inflamatoria.  una consecuencia de la colestasis extrahep\u00e1tica , adem\u00e1s de la insuficiencia hep\u00e1tica, es la hipertensi\u00f3n portal asociada a enteropat\u00eda hipertensiva. A su vez, la naturaleza inflamatoria de este tipo de enteropat\u00eda podr\u00eda influir en su evoluci\u00f3n, causando una patolog\u00eda vascular regional, caracteri zada por el desarrollo de circulaci\u00f3n colateral portosist\u00e9mica, as\u00ed como con inducci\u00f3n de angiog\u00e9nesis y linfangog\u00e9nesis parietal intestinal. Por esta raz\u00f3n se ha estudiado la respuesta de fase aguda sist\u00e9mica, el tipo de circulaci\u00f3n colateral portos ist\u00e9mica que se establece y, por m\u00e9todos inmunohistoqu\u00edmicos, la angiog\u00e9nesis y la linfangiog\u00e9nesis intestinal.  para la realizaci\u00f3n de este trabajo se han utilizado 70 ratas macho de la cepa wistar, perteneciendo 29 de ellas a un grupo de animales p seudooperados (ps) y 41 a un grupo  con colestasis microquirurgica  (cm).   En las ratas del grupo cm se ha realizado una t\u00e9cnica de colestasis microquirugica experimental, mientras que a las ratas pertenecientes al grupo ps se les ha realizado un ab ordaje quir\u00fargico similar \u00fanicamente disecando la v\u00eda biliar. Los animales han sido sacrificados a las 6 semanas de postoperatorio estudi\u00e1ndose la circulaci\u00f3n colateral desarrollada, la vasculopatia venosa mesenterica y obteni\u00e9ndose muestras de disti ntos \u00f3rganos, incluyendo h\u00edgado e intestino delgado. Tambi\u00e9n se obtuvieron muestras sangu\u00edneas de estos animales con el fin de estudiar los valores s\u00e9ricos de bilirrubina total y directa, alt, ast, ggt, ldh, fosfatasa alcalina, creatinina, urea, alb\u00fa mina y \u00e1cidos biliares, asi como para determinar las prote\u00ednas de fase aguda ?1-map y ?1-agp. Adem\u00e1s, se ha realizado un estudio microsc\u00f3pico e histopatol\u00f3gico  del h\u00edgado, estudiando la fibrosis hep\u00e1tica con t\u00e9cnicas histomorfometricas utilizando un a tinci\u00f3n con rojo sirio. Por ultimo se ha realizado un estudio inmunohistoqu\u00edmico del ileon para determinar la angiogenesis y linfangiogenesis, para lo cual se han utilizado anticuerpos anti-vegf y anti-prox1, y se ha realizado una t\u00e9cnica western b<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Enteropatia inflamatoria en la colestasis extrahep\u00e1tica microquir\u00fargi-ca experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Enteropatia inflamatoria en la colestasis extrahep\u00e1tica microquir\u00fargi-ca experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Felipe Vicente Collado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/11\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Dieter Brandau Ballnet<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  victoria Diago santamaria <\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Felipe Vicente Collado Null los pacientes con colestasis obstructiva sufren una elevada morbi-mortalidad. Esto se debe a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[926,198930,12622],"class_list":["post-96990","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-dieter-brandau-ballnet","tag-felipe-vicente-collado","tag-maria-victoria-diago-santamaria"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/96990","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=96990"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/96990\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=96990"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=96990"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=96990"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}