{"id":97005,"date":"2009-04-11T00:00:00","date_gmt":"2009-04-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-y-evaluacion-de-un-test-diagnostico-frente-al-coronavirus-responsable-del-sindrome-respiratorio-agudo-severo-sars\/"},"modified":"2009-04-11T00:00:00","modified_gmt":"2009-04-11T00:00:00","slug":"desarrollo-y-evaluacion-de-un-test-diagnostico-frente-al-coronavirus-responsable-del-sindrome-respiratorio-agudo-severo-sars","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/desarrollo-y-evaluacion-de-un-test-diagnostico-frente-al-coronavirus-responsable-del-sindrome-respiratorio-agudo-severo-sars\/","title":{"rendered":"Desarrollo y evaluacion de un test diagnostico frente al coronavirus responsable del sindrome respiratorio agudo severo (sars)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luis Gabriel Gimenez Lirola <\/strong><\/h2>\n<p>Se describe un nuevo test elisa para la detecci\u00f3n del coranavirus causal del s\u00edndrome respiratorio agudo severo o sars, basado en la detecci\u00f3n de inmunoglobulinas g y m. Para la detecci\u00f3n se hace  uso de una mezcla de 4 ant\u00edgenos recombinantes obtenidos a partir del material gen\u00e9tico del virus. Los fragmentos designados como ant\u00edgenos forman parte de dos prot\u00ednas estructurales del sars-cov: s251-683, polip\u00e9ptido incluido en la prote\u00edna de las esp\u00edculas (s) y otros tres fragmentos recombinantes correspondientes a la prote\u00edna de la nucleoc\u00e1pside (n), y que la contienen pr\u00e1cticamente en su totalidad. La inmuinizaci\u00f3n de un conejo con esta mezcla permiti\u00f3 obtener un anticuerpo policlonal capaz de reconocer c\u00e9lulas infectadas con el saras-cov, validando la aefectividad de los ant\u00edgenos recombinantes obtenidos. El test de elisa elaborado fue testado con 100 controles sanos y 20 pacientes infectados por el sars-cov, dando lugar a una especificidad del 99% y una sensibilidad del 90%. Estudios desarrollados con los polip\u00e9ptidos recombinantes por separado, demostraron que la uni\u00f3n de los 4 ant\u00edgenos obtenidos y correspondientes a ambas prot\u00ednas virales, es m\u00e1s efectiva para el serodiagn\u00f3stico de esta enfermedad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo y evaluacion de un test diagnostico frente al coronavirus responsable del sindrome respiratorio agudo severo (sars)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo y evaluacion de un test diagnostico frente al coronavirus responsable del sindrome respiratorio agudo severo (sars) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luis Gabriel Gimenez Lirola <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Ja\u00e9n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/11\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ana Camacho Paez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: dolores Gonz\u00e1lez pacanowska <\/li>\n<li>Jos\u00e9 Antonio Carrillo avila (vocal)<\/li>\n<li>carolina isabel Roldan  fontana (vocal)<\/li>\n<li>Jos\u00e9 Gutierrez fernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luis Gabriel Gimenez Lirola Se describe un nuevo test elisa para la detecci\u00f3n del coranavirus causal del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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